Herbicidal pyridine N-oxide sulfonylureas

ABSTRACT

This invention relates to pyridine N-oxide sulfonylurea herbicides, agriculturally suitable compositions containing them and their method-of-use as preemergent and/or postemergent herbicides or plant growth regulants.

RELATED APPLICATION

This application is a continuation-in-part of copending application U.S. Ser. No. 929,980, filed Nov. 12, 1986, abandoned.

BACKGROUND OF THE INVENTION

EP-A-No. 13,480 discloses herbicidal sulfonamides of the formula ##STR1## wherein R₁ is H, Cl, Br, F, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ alkylthio, NO₂ or CO₂ R₅.

U.S. Pat. No. 4,339,267 discloses herbicidal sulfonamides of the formula ##STR2## wherein R₄ is H, Cl, Br, F, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, NO₂, CO₂ R₆ or SR₁₃.

U.S. Pat. No. 4,342,587 discloses herbicidal sulfonamides of the formula ##STR3## wherein B is Cl or Br.

U.S. Pat. No. 4,456,469 discloses herbicidal sulfonamides of the formula ##STR4## wherein R is C₁ -C₆ alkyl, C₃ -C₆ alkenyl, C₂ -C₄ alkoxyalkyl, C₅ -C₆ cycloalkyl, R'OCH₂ CH₂ OCH₂, R'OCH₂ CH₂ OCH₂ CH₂, ##STR5## CF₃, CF₃ CH₂, HGLCCF₂ or HCF₂ ; and Z is H, F, Cl, Br, CH₃, OCH₃ or SCH₃.

U.S. Pat. No. 4,487,626 discloses herbicidal sulfonamides of the formula ##STR6## wherein A is ##STR7## and R₂ is H, F, Cl, Br, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, NO₂, CO₂ R₁₅, S(O)_(m) R₁₆, SO₂ NR₁₈ R₁₉ or SO₂ N(OCH₃)CH₃.

U.S. Pat. No. 4,421,550 discloses herbicidal sulfonamides of the formula ##STR8## wherein Z is ##STR9## and R₁₆ is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, F, Cl, Br, CF₃, CO₂ R₂₀, SO₂ NR₁₀ R₁₁, SO₂ N(OCH₃)CH₃ or S(O)_(n) R₁₃.

U.S. Pat. No. 4,496,392 discloses herbicidal sulfonamides of the formula ##STR10## wherein R₃ is Cl, SO₂ CH₃ or SO₂ N(CH₃)₂.

EP-A-No. 84,224 discloses herbicidal sulfonamides of the formula ##STR11## wherein A is ##STR12## and R₁₆ is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, F, Cl, Br, CF₃, CO₂ R₉, SO₂ NR₁₀ R₁₁, SO₂ N(OCH₃)CH₃ or S(O)_(n) R₁₃.

EP-A-No. 125,846 discloses herbicidal sulfonamides of the formula ##STR13## wherein J is ##STR14## and R is Cl, SO₂ CH₃, SO₂ N(CH₃)₂, OCH₃, NO₂ or N(CH₃)₂.

EP-A-No. 155,767 discloses herbicidal sulfonamides of the formula ##STR15## wherein J is ##STR16## and R₅ is H, CH₃, Cl, Br, CO₂ R₁₅, C(O)NR₁₆ R₁₇, SO₂ NR₁₆ R₁₇, SO₂ N(OCH₃)CH₃, SO₂ R₁₈ or NO₂.

EP-A-No. 161,905 discloses herbicidal sulfonamides of the formula ##STR17## wherein R₄ is CH₃, CH₂ CH₃, OCH₃, OCH₂ CH₃, F, Cl, Br, SO₂ NR₁₆ R₁₇, SO₂ N(OCH₃)CH₃, S(O)_(n) R₁₉, C₃ -C₄ alkenyloxy or C₃ -C₄ alkynyloxy.

EP-A-No. 164,269 discloses herbicidal sulfonamides of the formula ##STR18## wherein R₄ is CH₃, CH₂ CH₃, OCH₃, OCH₂ CH₃, F, Cl, Br, SO₂ NR₁₁ R₁₂, SO₂ N(OCH₃)CH₃ or S(O)_(n) R₁₃.

EP-A-No. 171,286 discloses herbicidal sulfonamides of the formula ##STR19## wherein R₄ is CH₃, CH₂ CH₃, OCH₃, OCH₂ CH₃, F, Cl, Br, SO₂ NR₁₈ R₁₉, SO₂ N(OCH₃)CH₃, S(O)_(n) R₂₁, C₃ -C₄ alkenyloxy, CH₂ OCH₃ or CH₂ OCH₂ CH₃.

EP-A-No. 187,489 discloses herbicidal sulfonamides of the formula ##STR20## wherein L is ##STR21## Q is an optionally substituted 3- or 4-membered ring; and W is substituted alkenyl or alkynyl.

SUMMARY OF THE INVENTION

This application pertains to novel compounds of Formula I, agriculturally suitable compositions containing them and their method-of-use as preemergent and/or postemergent herbicides or plant growth regulants. ##STR22## wherein J is ##STR23## wherein R is H or CH₃ ;

E is a single bond or CH₂ ;

W is O, S or NR_(x) ;

R_(x) is H, C₁ -C₃ alkyl or C₁ -C₃ alkoxy;

R₁ is H, F, Cl, Br, C₁ -C₃ alkyl, C₁ -C₃ haloalkyl, C₁ -C₃ alkoxy, C₁ -C₃ haloalkoxy or C₁ -C₃ thioalkyl;

R₂ is H, Cl, Br, F, C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, cyclopropyl optionally substituted by 1-4 halogen, cyclobutyl optionally substituted by 1-4 halogen, C₂ -C₄ alkenyl optionally substituted by halogen, C₂ -C₄ alkynyl optionally substituted by halogen, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₃ -C₄ alkenyloxy, C₃ -C₄ alkynyloxy, NO₂, CO₂ R₃, NR₄ R₅, S(O)_(n) R₆, SO₂ NR₇ R₈, C(O)NR₉ R₁₀, ##STR24## n is 0, 1 or 2; R₃ is C₁ -C₃ alkyl, C₂ -C₃ haloalkyl, C₁ -C₃ alkoxy, C₃ -C₄ alkenyl, CH₂ (C₃ -C₅ cycloalkyl) or C₃ -C₄ alkynyl;

R₄ is H or C₁ -C₂ alkyl;

R₅ is C₁ -C₂ alkyl;

R₆ is C₁ -C₄ alkyl, C₃ -C₄ alkenyl, C₂ -C₄ alkoxyalkyl or C₁ -C₃ haloalkyl;

R₇ is H or C₁ -C₂ alkyl;

R₈ is C₁ -C₂ alkyl or C₁ -C₂ alkoxy;

R₉ is H or C₁ -C₃ alkyl;

R₁₀ is C₁ -C₃ alkyl;

R₁₁ is H or CH₃ ;

R₁₂ is H or CH₃ ;

R₁₃ is H, C₁ -C₃ alkyl, allyl, C₁ -C₃ haloalkyl or C₁ -C₃ alkyl substituted with C₁ -C₂ alkoxy;

R₁₃ ' is H, C₁ -C₃ alkyl, C₁ -C₃ haloalkyl, allyl, C₁ -C₂ alkoxy, C₁ -C₂ haloalkoxy or C₁ -C₂ alkylthio;

R₁₃ " is H, C₁ -C₃ alkyl, allyl or C₁ -C₃ haloalkyl;

R₁₄ is C₁ -C₃ alkyl, CH₂ OCH₃ or CH₂ CN;

A is ##STR25## X is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkyl, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, halogen, C₂ -C₅ alkoxyalkyl, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino or di(C₁ -C₃ alkyl)amino;

Y is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, C₂ -C₅ alkoxyalkyl, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino, di(C₁ -C₃ alkyl)amino, C₃ -C₄ alkenyloxy, C₃ -C₄ alkynyloxy, C₂ -C₅ alkylthioalkyl, C₂ -C₅ alkylsulfinylalkyl, C₂ -C₅ alkylsulfonylalkyl, C₁ -C₄ haloalkyl, C₂ -C₄ alkynyl, C₃ -C₅ cycloalkyl, azido, cyano, ##STR26## or N(OCH₃)CH₃ ; m is 2 or 3;

Q₁ and Q₂ are independently O or S;

R_(a) is H or C₁ -C₃ alkyl;

R_(b) and R_(c) are independently C₁ -C₃ alkyl;

Z is CH, N, CCH₃, CC₂ H₅, CCl or CBr;

Y₁ is O or CH₂ ;

X₁ is CH₃, OCH₃, OC₂ H₅ or OCF₂ H;

X₂ is CH₃, C₂ H₅ or CH₂ CF₃ ;

Y₂ is OCH₃, OC₂ H₅, SCH₃, SC₂ H₅, CH₃ or CH₂ CH₃ ;

X₃ is CH₃ or OCH₃ ;

Y₃ is H or CH₃ ;

X₄ is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃ or Cl;

Y₄ is CH₃, OCH₃, OC₂ H₅ or Cl;

and their agriculturally suitable salts; provided that

(1) when X is halogen, then Z is CH and Y is OCH₃, OC₂ H₅, NH₂, NHCH₃, N(CH₃)₂, OCF₂ H, OCF₂ Br or N(OCH₃)CH₃ ;

(2) when X or Y is C₁ haloalkoxy, then Z is CH;

(3) when W is S, then R is H, E is a single bond, A is A-1, Z is CH or N, and Y is CH₃, OCH₃, OC₂ H₅, CH₂ OCH₃, C₂ H₅, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH(OCH₃)₂ or ##STR27## (4) when the total number of carbon atoms of X and Y is greater than four, then the combined number of carbons of R₁ and R₂ is less than or equal to six; and

(5) X₄ and Y₄ are not simultaneously Cl.

In the above definitions, the term "alkyl", used either alone or in compound words such as "alkylthio" or "haloalkyl", denotes straight chain or branched alkyl, e.g., methyl, ethyl, n-propyl, isopropyl or the different butyl isomers.

Alkoxy denotes methoxy, ethoxy, n-propoxy, isopropoxy and the different butoxy isomers.

Alkenyl denotes straight chain or branched alkenes, e.g., vinyl, 1-propenyl, 2-propenyl, 3-propenyl and the different butenyl isomers.

Alkynyl denotes straight chain or branched alkynes, e.g., ethynyl, 1-propynyl, 2-propynyl and the different butynyl isomers.

The term "halogen", either alone or in compound words such as "haloalkyl", denotes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as "haloalkyl" said alkyl may be monohalogenated or fully substituted with halogen atoms, which may be the same or different. Examples of haloalkyl include CH₂ CH₂ F, CF₂ CF₃ and CH₂ CHFCl.

Similarly, the terms haloalkoxy and haloalkylthio would include groups which are mono- or poly-substituted with halogen atoms, which may be the same or different.

The total number of carbon atoms in a substituent group is indicated by the C_(i) -C_(j) prefix where i and j are numbers from 1 to 5. For example, C₂ -C₄ alkenyl would designate ethenyl through butenyl.

Preferred for reasons of increased ease of synthesis and/or greater herbicidal efficacy are:

1. Compounds of Formula I where

X is C₁ -C₂ alkyl, C₁ -C₂ alkoxy, Cl, F, Br, I, OCF₂ H, CH₂ F, CF₃, OCH₂ CH₂ F, OCH₂ CHF₂, OCH₂ CF₃, CH₂ Cl or CH₂ Br; and

Y is H, C₁ -C₂ alkyl, C₁ -C₂ alkoxy, CH₂ OCH₃, CH₂ OCH₂ CH₃, NHCH₃, N(OCH₃)CH₃, N(CH₃)₂, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH₂ SCH₃, C(O)R_(a), ##STR28## OCF₂ H, SCF₂ H, OCF₂ Br, cyclopropyl, C.tbd.CH or C.tbd.CCH₃ ;

Z is CH or N; and

R_(a) is H or CH₃.

2. Compounds of Preferred 1 where

E is a single bond;

W is O; and

R₁ is H, F, Cl, Br, CH₃, C₁ haloalkyl or OCH₃.

3. Compounds of Preferred 1 where

E is CH₂ ;

W is O; and

R₁ is H, F, Cl, Br, CH₃ or OCH₃.

4. Compounds of Preferred 2 where

R₂ is H, Cl, Br, F, C₁ -C₂ alkyl, C₁ -C₂ haloalkyl, cyclopropyl, C₁ -C₂ alkoxy, C₁ -C₂ haloalkoxy, CF═CFCl, CF═CFCF₃, NO₂, CO₂ R₃, NR₄ R₅, S(O)_(n) R₆, SO₂ NR₇ R₈, SO₂ N(OCH₃)CH₃, C(O)NR₉ R₁₀, R₂ -A, R₂ -B, R₂ -E, R₂ -J, R₂ -N, R₂ -Q, R₂ -R, R₂ -X, R₂ -Y, R₂ -AB, R₂ -AC or R₂ -AD;

R₃ is CH₃, CH₂ CH₃, CH₂ CH₂ OCH₃ or CH₂ CH₂ Cl;

R₄ is H or CH₃ ;

R₆ is C₁ -C₃ alkyl, C₁ -C₃ haloalkyl or allyl;

R₇ is H or CH₃ ;

R₈ is C₁ -C₂ alkyl

R₉ is H or CH₃ ;

R₁₀ is CH₃ or CH₂ CH₃ ;

R₁₃ is H, CH₃, CH₂ CH₃ or CH₂ CH₂ OCH₃ ; and

R₁₃ " is H, CH₃ or CH₂ CH₃.

5. Compounds of Preferred 4 where

X is CH₃, OCH₃, OCH₂ CH₃, Cl, OCF₂ H or OCH₂ CF₃ ;

Y is CH₃, OCH₃, CH₂ CH₃, CH₂ OCH₃, NHCH₃ or CH(OCH₃)₂.

6. Compounds of Preferred 5 where

J is J₁ ; and

A is A-1.

7. Compounds of Preferred 5 where

J is J₂ ; and

A is A-1.

8. Compounds of Preferred 5 where

J is J₃ ; and

A is A-1.

9. Compounds of Preferred 5 where

J is J₄ ; and

A is A-1.

Specifically preferred for reasons of greatest ease of synthesis and/or greatest herbicidal efficacy are:

N[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-methyl-2-pyridinesulfonamide-1-oxide, m.p. 155°-157° C.; and

N[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl]-2-pyridinesulfonamide-1-oxide, m.p. 172°-176° C.

DETAILED DESCRIPTION OF THE INVENTION

Synthesis

Compounds of Formula I can be prepared by one or more of the procedures shown in Equations 1, 4, and 5. J, R, and A are as previously defined. ##STR29##

The reaction of Equation 1 is best carried out in an inert aprotic organic solvent such as dichloromethane, 1,2-dichloroethane, tetrahydrofuran, or acetonitrile, at a temperature between 20° and 85° C. The order of addition is not critical; however, it is often convenient to add the sulfonyl isocyanate or a solution of it in the reaction solvent, to a stirred suspension of the amine.

In some cases, the desired product is insoluble in the reaction solvent at ambient temperature and crystallizes from it in pure form. Products soluble in the reaction solvent are isolated by evaporation of the solvent. Compounds of Formula I then may be purified by trituration of the evaporation residue with solvents such as 1-chlorobutane or ethyl ether and filtration, by recrystallization from mixtures of solvents such as 1,2-dichloroethane, 1-chlorobutane and heptane or by chromatography on silica gel.

Sulfonyl isocyanates (II, W is O) are known in the art and are prepared from the corresponding sulfonamides (IV) by one of the following two general methods. ##STR30##

The sulfonamide IV is reacted with an alkyl isocyanate (e.g., n-butyl isocyanate) in a solvent whose boiling point is above 135° C., such as xylene. The reaction can optionally be carried out in the presence of a catalytic amount of 1,4-diaza[2.2.2]bicyclooctane (DABCO). The reaction mixture is heated to 135°-140° C. and held at that temperature for 5-60 minutes, after which phosgene is slowly added at such a rate that the temperature remains between 133 and 135° C. When the consumption of phosgene has ceased, the mixture is cooled and filtered to remove insoluble material. Finally, the solvent, alkyl isocyanate, and excess phosgene are evaporated, leaving the sulfonyl isocyanate (II).

If desired, the alkyl isocyanate-sulfonamide adduct can be made and isolated before reaction with the phosgene. In this case the sulfonamide (IV), alkyl isocyanate, and anhydrous base (e.g, K₂ CO₃) in a polar, aprotic solvent (e.g. acetone, butanone, or acetonitrile) are mixed and heated under reflux for 1 to 6 hours. The reaction mixture is then diluted with water, and the pH is adjusted to about 3 with acid (e.g. HCl, H₂ SO₄). The adduct is filtered out and dried, and then reacted with phosgene as described above. This procedure modification is especially useful when sulfonamide (IV) is high melting and has low solubility in the phosgenation solvent.

Sulfonyl isocyanates (II, W is O) can also be prepared by the following method. ##STR31##

The sulfonamide (IV) is heated at reflux in an excess of thionyl chloride. The reaction is continued until the sulfonamide protons are no longer detectable in the proton magnetic resonance spectrum. From 16 hours to 5 days is typically sufficient for complete conversion to the thionylamide (V) (Equation 3a).

The thionyl chloride is evaporated and the residue is treated with an inert solvent (e.g. toluene) containing at least one equivalent (typically 2-3 equivalents) of phosgene. A catalytic amount of pyridine (typically 0.1 equivalent ) is added, and the mixture is heated to about 60°-140° C., with 80°-100° C. preferred. Conversion to the isocyanate (II, W is O) is usually substantially complete within 15 minutes to 3 hours (Equation 3b). The mixture is then cooled and filtered, and the solvent is evaporated, leaving the sulfonyl isocyanate (II, W is O).

Sulfonyl isothiocyanates (II, W is S) are known in the art and are prepared from the corresponding sulfonamides (IV) by reaction with carbon disulfide and potassium hydroxide followed by treatment of the resulting dipotassium salt VI with phosgene. Such a procedure is described in Arch. Pharm. 299, 174 (1966).

Many of the compounds of Formula I can be prepared by the procedure shown in Equation 4. ##STR32##

The reaction of Equation 4 is carried out by contacting phenylcarbamates or phenylthiocarbamates of Formula VI with aminoheterocycles of Formula III in an inert organic solvent such as dioxane or tetrahydrofuran at temperatures of about 20°-100° C. for a period of about one-half to twenty-four hours. The product can be isolated by evaporation of the reaction solvent and purified by methods previously described.

Phenylcarbamates and phenylthiocarbamates of Formula VI can be prepared by the methods described, or modifications thereof known to those skilled in the art, in U.S. Pat. No. 4,443,243.

Alternatively, many of the compounds of Formula I can be prepared by the method described in Equation 5. ##STR33##

The reaction of Equation 5 can be carried out by contacting equimolar amounts of a sulfonamide of Formula IV with a heterocyclic phenylcarbamate or phenylthiocarbamate of Formula VII in the presence of a base such as 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), by methods analogous to those described in South African Patent Application 83/0441. The phenylcarbamates and phenylthiocarbamates of Formula VII can be prepared by methods, or modifications thereof known to those skilled in the art, described in South African Patent Application No. 82/5671 and South African Patent Application No. 82/5045.

The sulfonamides IV of this invention may be prepared in a variety of ways, some of which are described in Equations 6 through 13.

For example, pyridine sulfonamides such as 1 may be oxidized directly to the corresponding N-oxide 2, using a variety of oxidants. Some of the oxidants of choice are m-chloroperoxybenzoic acid, CF₃ CO₃ H, H₂ O₂, etc. This is outlined in Equation 6. ##STR34##

In Equation 6, R₁ and R₂ are as previously defined, with the exception that R₂ cannot be a group which will react with a strong oxidant (i.e., thioalkyl, alkenyl, etc.). In addition, isomers of sulfonamide 2, that is sulfonamides such as 3, 4 and 5 may also be prepared in the same manner as outlined in Equation 6. ##STR35##

Preparation of pyridine sulfonamides such as 1 (and its isomers) is well known to one skilled in the art. For further details pertaining to the preparation of pyridine sulfonamides see, U.S. Pat No. 4,544,401 (3-pyridine sulfonamides), U.S. Pat. No. 4,435,206 (2-pyridine sulfonamides), U.S. Pat. Nos. 4,456,469, 4,342,587 and EP-A-No. 165,753.

Preparation of sulfonamides such as 2, 3, 4 and 5 may also be accomplished utilizing organo lithium chemistry as outlined in Equations 7 through 10. ##STR36##

The methodology outlined in Equations 7-10 is applicable to a wide variety of derivatives where R₁ and R₂ are compatible with organo metallic conditions. For example, sulfonamide 2a where R₁ is H and R₂ is CO₂ CH₃ may be prepared as outlined in Equation 11. ##STR37##

An alternate synthesis of sulfonamides such as 2, (also applicable to other isomers) is to introduce the n-oxide functionality into the pyridine ring at the beginning of the synthetic scheme rather than the end of the synthesis. This is outlined in Equation 12. ##STR38##

Preparation of sulfonamides such as 2 where R₂ is incompatible with reagents such as BuLi or LDA may be carried out in a variety of ways. For example, preparation of sulfonamides 10 and 12 utilizing fluoride 11 is outlined in Equation 13. ##STR39##

In Equation 13, introduction of the N-oxide functionality may be strategically done at any point of the synthesis. This then allows for the introduction of a functionality in R₂ which is sensitive to strong oxidants (i.e., thioalkyl, alkenyl, etc.) as discussed in Equation 6.

For further details pertaining to lithiations of pyridine ring systems see, Epsztarjn et al., Tetrahedron Lett., 4739 (1980); Snieckus et al., J. Am. Chem. Soc., 102, 1457 (1980); Kuraishi et al., Tet. Lett., 2049 (1983); Meyers et al., J. Org. Chem., 47, 2633 (1982); Taylor et al., J. Org. Chem., 48, 4156 (1983) and Breant et al., Synthesis, 822 (1983).

For further details pertaining to the oxidation of pyridines to pyridine N-oxides see, Evans et al., Rec. Trav., 78, 408 (1959).

For a general treatment of pyridines and pyridine N-oxides see, Katritzky, A. R., and Rees, C. W., "Comprehensive Heterocyclic Chemistry", Vol. 2, Pergamon Press, Oxford, New York, Part 2A, 1984.

The synthesis of heterocyclic amines such as those represented by Formula III has been reviewed in "The Chemistry of Heterocyclic Compounds," a series published by Interscience Publ., New York and London. Aminopyrimidines are described by D. J. Brown in "The Pyrimidines," Vol. XVI of the series mentioned above which is herein incorporated by reference. The 2-amino-1,3,5-triazines of Formula III, where A is A-1 and Z is N, can be prepared according to methods described by E. M. Smolin and L. Rapaport in "s-Triazines and Derivatives," Vol. XIII.

Pyrimidines of Formula III, where A is A-1 and Y is an acetal or thioacetal substituent, can be prepared by methods taught in European Patent Application No. 84,224 (published July 27, 1983).

Pyrimidines of Formula III, where A is A-1 and Y is cyclopropyl or OCF₂ H can be synthesized according to the methods taught in U.S. Pat. No. 4,515,626 and U.S. Pat. No. 4,540,782, respectively.

Compounds of Formula III, where A is A-2 or A-3, can be prepared by procedures disclosed in U.S. Pat. No. 4,339,267.

Compounds of Formula III, where A is A-4, can be prepared by methods taught in U.S. Pat. No. 4,487,626.

Additional references dealing with the synthesis of bicyclic pyrimidines of Formula III, where A is A-2, A-3, or A-4 are Braker, Sheehan, Spitzmiller and Lott, J. Am. Chem. Soc., 69, 3072 (1947); Mitler and Bhattachanya, Quart. J. Indian Chem. Soc., 4, 152 (1927); Shrage and Hitchings, J. Org. Chem., 16, 1153 (1951); Caldwell, Kornfeld and Donnell, J. Am. Chem. Soc., 63, 2188 (1941); and Fissekis, Myles and Brown, J. Org. Chem., 29, 2670 (1964).

Compounds of Formula III, where A is A-5, can be prepared by methods taught in U.S. Pat. No. 4,421,550.

Compounds of Formula III, where A is A-6, can be prepared by methods taught in the U.S. Pat. No. 4,496,392.

Compounds of Formula III, where A is A-7 can be prepared by methods taught in EP-A-No. 125,864.

Agriculturally suitable salts of compounds of Formula I are also useful herbicides and can be prepared in a number of ways known to the art. For example, metal salts can be made by contacting compounds of Formula I with a solution of an alkali or alkaline earth metal salt having a sufficiently basic anion (e.g., hydroxide, alkoxide, carbonate or hydroxide). Quaternary amine salts can be made by simlar techniques.

Salts of compounds of Formula I can also be prepared by exchange of one cation for another. Cationic exchange can be effected by direct contact of an aqueous solution of a salt of a compound of Formula I (e.g., alkali or quaternary amine salt) with a solution containing the cation to be exchanged. This method is most effective when the desired salt containing the exchanged cation is insoluble in water and can be separated by filtration.

Exchange may also beeffected by passing an aqueous solution of a salt of a compound of Formula I (e.g., an alkali metal or quaternary amine salt) through a column packed with a cation exchange resin containing the cation to be exchanged for that of the original salt and the desired product is eluted from the column. This method is particularly useful when the desired salt is water-soluble, e.g., a potassium sodium or calcium salt.

Acid addition salts, useful in this invention, can be obtained by reacting a compound of Formula I with a suitable acid, e.g., p-toluenesulfonic acid, trichloroacetic acid or the like.

The preparation of the compounds of this invention is further illustrated by the following specific examples. Unless otherwise indicated, temperatures are in degrees centigrade.

EXAMPLE 1 Preparation of 3-Methyl-2-(phenylmethylthio)pyridine

To a solution of NaH (2.4 g, 99 mmol) in 100 mL of DMF cooled to 0° C. is added benzylmercaptan (12.3 g, 99 mmol). The solution was allowed to warm to room temperature then recooled to 0° C. 2-Fluoro-3-methylpyridine in 10 mL DMF was added dropwise and stirred at room temperature overnight. The solution was diluted with H₂ O, extracted twice with Et₂ O, twice with EtOAc, and the combined organics washed twice with saturated NaHCO₃, dried and concentrated. The resulting oil was flash chromatographed (10% Et₂ O/hexane (v/v)) to yield 16.3 g of the desired product. NMR (200 MHz, CDCl₃) δ 2.24 (s, 3H), 4.50 (s, 2H), 6.9 (dd, 1H), 7.2 (m, 5H), 7.4 (d, 1H) and 8.3 (d, 1H).

EXAMPLE 2 Preparation of N-(1,1-Dimethylethyl)-3-methyl-2-pyridinesulfonamide

To a vigorously stirring mixture of 3-methyl-2-(phenylmethylthio)pyridine (25 g, 116 mmol) CH₂ Cl₂ (500 mL) and H₂ O (260 mL) cooled to 0° C. was added 45 mL concentrated HCl. Chlorox® (500 mL) was then added dropwise between 0° to -5° C. The reaction was stirred 1 hour at 0° C. and then extracted with CH₂ Cl₂. The organic extracts were cooled to -70° C. and tert-butylamine (50 mL) was added dropwise. The solution was allowed to slowly warm to room temperature, diluted with H₂ O and extracted with CH₂ Cl₂. The organics were dried and concentrated to an oil. The oil was triturated with Et₂ O/hexane to afford 10 g of the desired product, m.p. 107°-110° C.; NMR (200 MHz, CDCl₃) δ 1.27 (s, 9H), 2.68 (s, 3H), 5.138 (br s, 1H), 7.35 (dd, 1H), 7.62 (d, 1H) and 8.4 (d, 1H).

EXAMPLE 3 Preparation of N-(1,1-Dimethylethyl)-3-methyl-2-pyridinesulfonamide-1-oxide

To a stirring solution of 3-methyl-2-tert-butylpyridinesulfonamide (3.2 g, 14.0 mmol) in 100 mL of CH₂ Cl₂ was added m-chloroperoxybenzoic acid (2.8 g, 14.0 mmol). The solution was stirred overnight at room temperature, washed once with brine, twice with saturated NaHCO₃, dried and concentrated. The resulting oil was flash chromatographed (25% EtOAc/hexane (v/v)) to yield 3.0 g of the desired product, m.p. 124°-126° C. NMR (200 MHz, CDCl₃) δ 1.25 (s, 9H), 2.7 (s, 3H), 7.1 (br s, 1H), 7.26 (m, 2H) and 8.2 (d, 1H).

EXAMPLE 4 Preparation of 3-Methyl-2-pyridinesulfonamide-1-oxide

A mixture of the N-oxide of N-(1,1-dimethylethyl)-3-methyl-2-pyridinesulfonamide (2.5 g, 8.2 mmol) and 50 mL of CF₃ CO₂ H were stirred for 6 hours. The CF₃ CO₂ H was removed under vacuum and the resulting solids were washed with butyl chloride to afford 1 g of the desired product, m.p. 233°-235° C., (M⁺ =188, expected, 188).

EXAMPLE 5 Preparation of N-[(4,6-Dimethylpyrimidin-2-yl)aminocarbonyl]-3-methyl-2-pyridinesulfonamide-1-oxide

To a stirring solution of the N-oxide of 3-methyl-2-pyridinesulfonamide (150 mg, 0.79 mmol) and the phenylcarbamate of 4,6-dimethyl-2-aminopyridine (194 mg, 0.79 mmol) in 3 mL of CH₃ CN was added DBU (121 mg, 0.79 mmol). The solution was stirred for 15 minutes. Three mL of H₂ O, then 3 mL of 5% HCl was added to the reaction and the resulting solid was collected, m.p. 161°-163° C. NMR (200 MHz, d₆ -DMSO) δ 2.36 (s, 6H), 2.59 (s, 3H), 6.97 (s, 1H), 7.4 (d, 1H), 7.5 (d, 1H), 8.3 (d, 1H), 10.6 (br s, 1H) and 13.3 (br s, 1H).

EXAMPLE 6 Preparation of 3-Chloro-2-pyridinesulfonamide-1-oxide

To a stirring solution of 3-chloro-2-pyridinesulfonamide (2.5 g, 13.0 mmol) in 35 mL of trifluoroacetic acid was added 30% H₂ O₂ (1.2 g, 35.1 mmol). The solution was concentrated to ˜15 mL, diluted with ethyl acetate, washed twice with brine, dried and concentrated. The resulting solid was flash chromatographed with EtOAc to afford the desired product, m.p. 195°-197° C.

EXAMPLE 7 Preparation of 3-Chloro-N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-2-pyridinesulfonamide-1-oxide

To a stirring solution of the N-oxide of 3-chloro-2-pyridinesulfonamide (85 mg, 0.4 mmol) and the phenyl carbamate of 4,6-dimethoxy-2-aminopyrimidine (114 mg, 0.40 mmol) in acetonitrile was added DBU (62 mg, 0.40 mmol). Addition of H₂ O followed by 5% HCl caused a precipitate to form which was collected, m.p. 144°-147° C. NMR (200 MHz, d₆ -DMSO) δ 3.91 (s, 6H), 5.998 (s, 1H), 7.7 (m, 2H), 8.4 (d, 1H), 10.8 (br s, 1H) and 13.1 (br s, 1H); IR (nujol) 1710 (s) cm⁻¹ ; mass spectrum m/e 390 (M⁺, calc. for C₁₂ H₁₂ ClN₅ O₆ S 389+1).

EXAMPLE 8 Preparation of 6-methylthio-3-carboxy-2-pyridinesulfonamide-1-oxide methyl ester

To a stirring solution of n-butyllithium in 150 ml of tetrahydrofuran cooled to -78° C. was added 6-methylthio-2-pyridine-t-butylsulfonamide-1-oxide (30 g, 10.9 mmol) dropwise. The solution was stirred for one hour at -78° C. followed by dropwise addition of methylchloroformate (5.1 g, 53.4 mmol). The solution was warmed to 0° C. and quenched with brine. The organic layer was separated, dryed and concentrated to an oil. The resulting oil was subjected to MPLC with a 25% EtOAc-hexane (v/v) to afford 710 mg of product. This was then submitted to trifluroacetic acid (25 ml) for 24 hours. Removal of the acid and triteration with BuCl afforded 400 mg of the desired sulfonamide: m.p. 199°-202; NMR (200 MHz, DMSO) δ 2.48 (s, 3H), 3.78 (s, 3H), 7.60 (br s, 2H); mass spectrum m/e 279 (M⁺, calc. for C₈ H.sub. 10 NO₅ S₂ 278+1).

                  COMPOUND TABLES                                                  ______________________________________                                         Structure of J Substituent                                                     in Tables I-IV                                                                 ______________________________________                                         Table I                                                                        J is J-1                                                                        ##STR40##                                                                     Table II                                                                       J is J-2                                                                        ##STR41##                                                                     Table III                                                                      J is J-3                                                                        ##STR42##                                                                     Table IV                                                                       J is J-4                                                                        ##STR43##                                                                     ______________________________________                                    

                                      TABLE I                                      __________________________________________________________________________     R  A  E W R.sub.1                                                                               R.sub.2    X     Y      Z  m.p.(°C.)                   __________________________________________________________________________     H  A-1                                                                               --                                                                               O H      H          CH.sub.3                                                                             CH.sub.3                                                                              CH 169-172                            H  A-1                                                                               --                                                                               O H      H          CH.sub.3                                                                             OCH.sub.3                                                                             CH 173-175                            H  A-1                                                                               --                                                                               O H      H          OCH.sub.3                                                                            OCH.sub.3                                                                             CH 179-183                            H  A-1                                                                               --                                                                               O H      H          CH.sub.3                                                                             CH.sub.3                                                                              N  149-166                            H  A-1                                                                               --                                                                               O H      H          CH.sub.3                                                                             OCH.sub.3                                                                             N  172-176                            H  A-1                                                                               --                                                                               O H      H          OCH.sub.3                                                                            OCH.sub.3                                                                             N  167-170                            H  A-1                                                                               --                                                                               O H      H          Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      Cl         CH.sub.3                                                                             CH.sub.3                                                                              CH 147-149                            H  A-1                                                                               --                                                                               O H      Cl         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      Cl         OCH.sub.3                                                                            OCH.sub.3                                                                             CH 144-147                            H  A-1                                                                               --                                                                               O H      Cl         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      Cl         CH.sub.3                                                                             OCH.sub.3                                                                             N  130-132                            H  A-1                                                                               --                                                                               O H      Cl         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      Cl         Cl    OCH.sub.3                                                                             CH 162-164                            H  A-1                                                                               --                                                                               O H      Br         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      Br         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      Br         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      Br         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      Br         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      Br         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      Br         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      F          CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      F          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      F          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      F          CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      F          CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      F          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      F          Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              CH 161-163                            H  A-1                                                                               --                                                                               O H      CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             CH 150-152                            H  A-1                                                                               --                                                                               O H      CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             CH 155-157                            H  A-1                                                                               --                                                                               O H      CH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             N  130-132                            H  A-1                                                                               --                                                                               O H      CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             N  156-158                            H  A-1                                                                               --                                                                               O H      CH.sub.3   Cl    OCH.sub.3                                                                             CH 160-162                            H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH 147-150                            H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH 158-160                            H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH 175-178                            H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N  179-181                            H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N  183-185                            H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH 181-183                            H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH 143-147                            H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH 189-191                            H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH.sub.2 CH.sub.3                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH.sub.2 CH.sub.3                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2 CH(CH.sub. 3).sub.2                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2 CH(CH.sub.3).sub.2                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      (CH.sub.2).sub.4 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             CH 178-180                            H  A-1                                                                               --                                                                               O H      CH.sub.2 Cl                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 Cl                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 Cl                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 Cl                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2 Br                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2 Br                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2 F Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                            Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                             CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                             CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                             CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                             Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                    Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 H CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 H CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 H OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 H CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CF.sub.2 H CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CF.sub.2 H OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CF.sub.2 H Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CCl.sub.2 H                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CCl.sub.2 H                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CCl.sub.2 H                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CCl.sub.2 H                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CCl.sub.2 H                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CCl.sub.2 H                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CCl.sub.2 H                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH(F)CH.sub.3                                                                    CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH(F)CH.sub.3                                                                    CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH(F)CH.sub.3                                                                    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH(Cl)CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH(Cl)CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH.sub.2 Br                                                                   OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH.sub.2 Br                                                                   Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      cyclopropyl                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH 167-169                            H  A-1                                                                               --                                                                               O H      cyclopropyl                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH 146-148                            H  A-1                                                                               --                                                                               O H      cyclopropyl                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH 178-180                            H  A-1                                                                               --                                                                               O H      cyclopropyl                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      cyclopropyl                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      cyclopropyl                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N  182-184                            H  A-1                                                                               --                                                                               O H      cyclopropyl                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR44## CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR45## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR46## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR47## CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR48## CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR49## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR50## Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR51## CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR52## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR53## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR54## CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR55## CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR56## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR57## Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR58## CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR59## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR60## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR61## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR62## CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR63## CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR64## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR65## Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      cyclobutyl CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      cyclobutyl CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      cyclobutyl OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      cyclobutyl CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      cyclobutyl CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      cyclobutyl OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      cyclobutyl Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CHCH.sub.2 CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CHCH.sub.2 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CHCH.sub.2 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CHCH.sub.2 CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CHCH.sub.2 CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CHCH.sub.2 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CHCH.sub.2 Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CFCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CFCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CHFCH.sub.2                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CHFCH.sub.2                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CHFCH.sub.2                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CHFCH.sub.2                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CCHCH.sub.3                                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CCH                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CCH                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CCH                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CCH                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CCH                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CCH                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CCH                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CCH        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CCH        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CCH        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CCH        CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CCH        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CCH        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CCCH.sub.2 F                                                                              Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CCCH.sub.2 F                                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CCCH.sub.2 F                                                                              CH.sub.3                                                                             OCH.sub. 3                                                                            CH                                    H  A-1                                                                               --                                                                               O H      CCCH.sub.2 F                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CCCH.sub.2 Cl                                                                     CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CCCH.sub.2 Cl                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CCCH.sub.2 Cl                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CCCH.sub.2 Cl                                                                     Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.3  Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                        Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2CH(CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2CH(CH.sub.3).sub.2                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 H                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 H                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 H                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 H                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCF.sub.2 H                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCF.sub.2 H                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCF.sub.2 H                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Br                                                                     CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Br                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Br                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Br                                                                     Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CCH                                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CCH                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CCH                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CCH                                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2CCH                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2CCH                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2CCH                                                                              Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      NO.sub.2   CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      NO.sub.2   CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      NO.sub.2   OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      NO.sub.2   CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      NO.sub.2   CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      NO.sub.2   OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      NO.sub.2   Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                              Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2C CH                                                                     CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                             CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                             CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                             CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                             Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.3  Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                        Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                       OCH.sub. 3                                                                           OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 OCH.sub.3                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2CCH                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH(CH.sub.3).sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SCH(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH(CH.sub.3).sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH(CH.sub.3).sub.2                                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.3 CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.3 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.3 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.3 CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SOCH.sub.3 CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SOCH.sub.3 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SOCH.sub.3 Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                              Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SONHCH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.2)CH.sub.3                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             Cl    OCH.sub. 3                                                                            CH                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                              Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CONHCH.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.2 CH.sub.3).sub.2                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.2 CH.sub.3).sub.2                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.2 CH.sub.3).sub.2                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CON(CH.sub.2 CH.sub.3).sub.2                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CON(CH.sub.2 CH.sub.3).sub.2                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CON(CH.sub.2 CH.sub.3).sub.2                                                              Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR66## CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR67## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR68## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR69## CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR70## CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR71## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR72## Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR73## CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR74## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR75## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR76## CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR77## CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR78## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR79## Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR80## CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR81## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR82## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR83## CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR84## CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR85## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR86## Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR87## CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR88## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR89## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR90## CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR91## CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR92## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR93## Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR94## CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR95## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR96## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR97## CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR98## CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR99## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR100##                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR101##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR102##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR103##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR104##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR105##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR106##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR107##                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR108##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR109##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR110##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR111##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR112##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR113##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR114##                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR115##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR116##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR117##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR118##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR119##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR120##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR121##                                                                               Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.3   Cl    OCH.sub.3                                                                             CH                                    CH.sub. 3                                                                         A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub. 2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH.sub.2 CH.sub.3                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH.sub.2 CH.sub.3                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH(CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH(CH.sub.3).sub.2                                                               Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl                                                                               Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR122##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR123##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR124##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR125##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR126##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR127##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR128##                                                                               Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR129##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR130##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR131##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR132##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR133##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR134##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR135##                                                                               Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR136##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR137##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR138##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR139##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR140##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR141##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR142##                                                                               Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub. 2 CH.sub.3                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2   CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2   CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2   OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2   CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2   CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2   OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2   Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub. 3                                                                         A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub. 2 CH.sub.2CCH                                                                     Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-F    CH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-F    CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-F    CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-F    CH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-F    CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-F    CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-F    CH.sub.3   Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-F    CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-F    CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-F    CH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-F    CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-F    CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-F    CH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-F    CH.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-F    CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-F    CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-F    CH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-F    CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-F    CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-F    CH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-F    CH(CH.sub.3).sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-F    CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-F    CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-F    CH(CH.sub.3)CH.sub.2 CH.sub.3                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-F    CH(CH.sub.3)CH.sub.2 CH.sub.3                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-F    CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-F    CH.sub.2 CH(CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-F    CH.sub.2 CH(CH.sub.3).sub.2                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-Cl   cyclopropyl                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-Cl   cyclopropyl                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-Cl   cyclopropyl                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-Cl   cyclopropyl                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-Cl   cyclopropyl                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-Cl   cyclopropyl                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-Cl   cyclopropyl                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR143##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR144##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR145##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR146##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR147##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR148##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR149##                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR150##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR151##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR152##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR153##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR154##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR155##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR156##                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR157##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR158##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR159##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR160##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR161##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR162##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-Cl                                                                                   ##STR163##                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             CH.sub.2                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Cl                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Br                                                                     CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Br                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Br                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Br                                                                     Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CCH                                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CCH                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CCH                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CCH                                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CCH                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CCH                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CCH                                                                              Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CHCH.sub.2                                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           NO.sub.2   CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           NO.sub.2   CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           NO.sub.2   OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           NO.sub.2   CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           NO.sub.2   CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           NO.sub.2   OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           NO.sub.2   Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub. 3                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                              Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub. 3                                                                            CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 4-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-SOCH.sub.3                                                                          H          CH.sub.3                                                                             CH.sub.3                                                                              CH 175-178                            H  A-1                                                                               --                                                                               O 6-SOCH.sub.3                                                                          H          CH.sub.3                                                                             OCH.sub.3                                                                             CH 163-166                            H  A-1                                                                               --                                                                               O 6-SOCH.sub.3                                                                          H          OCH.sub.3                                                                            OCH.sub.3                                                                             CH 214-217                            H  A-1                                                                               --                                                                               O 6-SOCH.sub.3                                                                          H          OCH.sub.3                                                                            CH.sub.3                                                                              N  170-172                            H  A-1                                                                               --                                                                               O 6-SOCH.sub.3                                                                          H          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH.sub.2CHCH.sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH.sub.2CHCH.sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH.sub.2CHCH.sub.2                                                                       Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH.sub.2 CH.sub.2 OCH.sub.3                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH.sub.2CCH                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH(CH.sub.3).sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH(CH.sub.3).sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH(CH.sub.3).sub.2                                                                       Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SOCH.sub.3 CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SOCH.sub.3 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SOCH.sub.3 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SOCH.sub.3 CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SOCH.sub.3 CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SOCH.sub.3 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SOCH.sub.3 Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SO.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-SCH.sub.3                                                                           SCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                              CH 174-176                            H  A-1                                                                               --                                                                               O 6-SCH.sub.3                                                                           SCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                             CH 169-171                            H  A-1                                                                               --                                                                               O 6-SCH.sub.3                                                                           H          CH.sub.3                                                                             CH.sub.3                                                                              CH 203-205                            H  A-1                                                                               --                                                                               O 6-SCH.sub.3                                                                           H          CH.sub.3                                                                             OCH.sub.3                                                                             CH 150-154                            H  A-1                                                                               --                                                                               O 6-SCH.sub.3                                                                           H          OCH.sub.3                                                                            OCH.sub.3                                                                             CH 189-192                            H  A-1                                                                               --                                                                               O 6-SCH.sub.3                                                                           H          CH.sub.3                                                                             OCH.sub.3                                                                             N  185-187                            H  A-1                                                                               --                                                                               O 6-SCH.sub.3                                                                           H          OCH.sub.3                                                                            OCH.sub.3                                                                             N  180-182                            H  A-1                                                                               --                                                                               O 6-SCH.sub.3                                                                           H          Cl    OCH.sub.3                                                                             CH 186-188                            __________________________________________________________________________     R  A  E W R.sub.1                                                                               R.sub.2    X.sub.1                                                                              Y.sub.1   m.p.(°C.)                   __________________________________________________________________________     H  A-2                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             O                                            H  A-2                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.2                                     H  A-2                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            O                                            H  A-2                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            CH.sub.2                                     H  A-2                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.2 CH.sub.3                                                                   O                                            H  A-2                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                          CH.sub.2                                     H  A-2                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             O                                            H  A-2                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            O                                            H  A-2                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                OCF.sub.2 H                                                                          CH.sub.2                                     H  A-3                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                           H  A-3                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                          H  A-3                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.2 CH.sub.3                                 H  A-3                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                        H  A-3                                                                               --                                                                               O H      Cl         CH.sub.3                                           H  A-3                                                                               --                                                                               O H      Cl         OCH.sub.3                                          H  A-3                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                         CH.sub.3                                           H  A-3                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                          __________________________________________________________________________     R  A  E W R.sub.1                                                                               R.sub.2    X.sub.1                                                                              Y.sub.3   m.p.(°C.)                   __________________________________________________________________________     H  A-4                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             H                                            H  A-4                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            H                                            H  A-4                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.2 CH.sub.3                                                                   H                                            H  A-4                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                          H                                            H  A-4                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                     H  A-4                                                                               --                                                                               O H      CO.sub.2 CH.sub. 3                                                                        OCH.sub.3                                                                            CH.sub.3                                     H  A-4                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                          CH.sub.3                                     __________________________________________________________________________     R  A  E W R.sub.1                                                                               R.sub.2    X.sub.2                                                                              Y.sub.2   m.p.(°C.)                   __________________________________________________________________________     H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                    H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.2 CH.sub.3                           H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             SCH.sub.3                                    H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             SCH.sub.2 CH.sub.3                           H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                     H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.2 CH.sub.3                            H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                    H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                    SCH.sub.3                                    H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                    OCH.sub.2 CH.sub.3                           H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 CF.sub.3                                                                    OCH.sub.3                                    __________________________________________________________________________     R  A  E W R.sub.1                                                                               R.sub.2    X.sub.3         m.p(°C.)                    __________________________________________________________________________     H  A-6                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                           H  A-6                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                          H  A-6                                                                               --                                                                               O H      NO.sub.2   CH.sub.3                                           H  A-6                                                                               --                                                                               O H      NO.sub.2   OCH.sub.3                                          __________________________________________________________________________     R  A  E W R.sub.1                                                                               R.sub.2    X.sub.4                                                                              Y.sub.4   m.p.(°C.)                   __________________________________________________________________________     H  A-7                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                     H  A-7                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                    H  A-7                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.2 CH.sub.3                           H  A-7                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             Cl                                           H  A-7                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            CH.sub.3                                     H  A-7                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                    H  A-7                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.2 CH.sub.3                                                                   OCH.sub.3                                    __________________________________________________________________________     R  A  E W R.sub.1                                                                               R.sub.2    X     Y      Z  m.p.(°C.)                   __________________________________________________________________________     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                    CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCF.sub.2 H                                                                           CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             SCF.sub.2 H                                                                           CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             SCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                    N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             NHCH.sub.3                                                                            N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             N(CH.sub.3).sub.2                                                                     N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.2 F                                                                            CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CCH    CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             cyclopropyl                                                                           CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CN     CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                     CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                    CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            SCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCF.sub.2 H                                                                           CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            CH.sub.2 F                                                                            CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                     N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            NHCH.sub.3                                                                            N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            CN     CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                          CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                          OCH.sub.2 CH.sub.3                                                                    CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                          CH.sub.2 CH.sub.3                                                                     CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                          CH.sub.2 F                                                                            CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                          SCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                          N(CH.sub.3).sub.2                                                                     N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                          NHCH.sub.3                                                                            N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 OCH.sub.3                                                                   OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 OCH.sub.3                                                                   OCH.sub.2 CH.sub.3                                                                    CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 OCH.sub.3                                                                   CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 OCH.sub.3                                                                   CH.sub.2 F                                                                            CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 OCH.sub.3                                                                   CH.sub.2 Cl                                                                           CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 OCH.sub.3                                                                   CH.sub.2 Br                                                                           CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         SCF.sub.2 H                                                                          OCH.sub.2 CH.sub.3                                                                    CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         SCF.sub.2 H                                                                          CH.sub.2 CH.sub.3                                                                     CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         SCF.sub.2 H                                                                          CH.sub.2 F                                                                            CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         SCF.sub.2 H                                                                          NHCH.sub.3                                                                            N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         N(CH.sub. 3).sub.2                                                                   OCH.sub.2 CH.sub.3                                                                    CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         N(CH.sub.3).sub.2                                                                    CH.sub.2 CH.sub.3                                                                     CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         N(CH.sub.3).sub.2                                                                    CH.sub.2 F                                                                            CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         N(CH.sub.3).sub.2                                                                    CH.sub.2 OCH.sub.3                                                                    CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         N(CH.sub.3).sub.2                                                                    cyclopropyl                                                                           CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CCH   CH.sub.2 CH.sub.3                                                                     CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CCH   OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CCH   N(CH.sub.3).sub.2                                                                     N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CCH   OCH.sub.2 CH.sub.3                                                                    CH                                    __________________________________________________________________________

                                      TABLE II                                     __________________________________________________________________________                                                     m.p.                           R  A  E  W  R.sub.1                                                                               R.sub.2     X     Y      Z   (°C.)                   __________________________________________________________________________     H  A-1                                                                               -- O  H      H           CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      H           CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      H           OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      H           CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      H           CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      H           OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      H           Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      Cl          CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      Cl          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      Cl          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      Cl          CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      Cl          CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      Cl          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      Cl          Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      Br          CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      Br          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      Br          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      Br          CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      Br          CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      Br          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      Br          Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      F           CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      F           CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      F           OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      F           CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      F           CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      F           OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      F           Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.3    CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CH.sub.3    CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.3    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.3    CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CH.sub.3    CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH.sub.3    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH.sub.3    Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH(CH.sub. 3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH(CH.sub.3).sub.2                                                                         Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CH.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH(CH.sub.3)CH.sub.2 CH.sub.3                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH(CH.sub.3)CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CH.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH.sub.2 CH(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH.sub.2 CH(CH.sub.3).sub.2                                                                Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.2 Cl CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CH.sub.2 Cl CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.2 Cl OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.2 Cl CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CH.sub.2 Br CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH.sub.2 Br OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH.sub.2 F  Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH(Cl)CH.sub.3                                                                             CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CH(Cl)CH.sub.3                                                                             CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH(Cl)CH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH(Cl)CH.sub.3                                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CH(Cl)CH.sub.3                                                                             CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH(Cl)CH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH(Cl)CH.sub.3                                                                             Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH(F)CH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CH(F)CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH(F)CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH(F)CH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CH(F)CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH(F)CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH(F)CH.sub.3                                                                              Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH(F)CH.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CH(F)CH.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH(F)CH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH(F)CH.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CH(F)CH.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH(F)CH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH(F)CH.sub.2 CH.sub.3                                                                     Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CF.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CF.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CF.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CF.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CF.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CF.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CF.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CF.sub.2 H  CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CF.sub.2 H  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CF.sub.2 H  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CF.sub.2 H  CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CF.sub.2 H  CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CF.sub.2 H  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CF.sub.2 H  Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CCl.sub.2 H CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CCl.sub.2 H CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CCl.sub.2 H OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CCl.sub.2 H CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CCl.sub.2 H CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CCl.sub.2 H OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CCl.sub.2 H Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.2 CH(F)CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CH.sub.2 CH(F)CH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.2 CH(F)CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH(CH.sub.3)CH(Cl)CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CH(CH.sub.3)CH(Cl)CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH(CH.sub.3)CH.sub.2 Br                                                                    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH(CH.sub.3)CH.sub.2 Br                                                                    Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      cyclopropyl CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      cyclopropyl CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      cyclopropyl OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      cyclopropyl CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      cyclopropyl CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      cyclopropyl OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      cyclopropyl Cl    OCH.sub.3                                                                             CH                                  H  A-1                                                                               --                                                                                O  H                                                                                     ##STR164##  CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               --                                                                                O  H                                                                                     ##STR165##  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               --                                                                                O  H                                                                                     ##STR166##  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               --                                                                                O  H                                                                                     ##STR167##  CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               --                                                                                O  H                                                                                     ##STR168##  CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               --                                                                                O  H                                                                                     ##STR169##  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               --                                                                                O  H                                                                                     ##STR170##  Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               --                                                                                O  H                                                                                     ##STR171##  CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               --                                                                                O  H                                                                                     ##STR172##  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               --                                                                                O  H                                                                                     ##STR173##  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               --                                                                                O  H                                                                                     ##STR174##  CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               --                                                                                O   H                                                                                    ##STR175##  CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               --                                                                                O  H                                                                                     ##STR176##  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               --                                                                                O  H                                                                                     ##STR177##  Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               --                                                                                O  H                                                                                     ##STR178##  CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               --                                                                                O  H                                                                                     ##STR179##  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               --                                                                                O  H                                                                                     ##STR180##  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               --                                                                                O  H                                                                                     ##STR181##  CH.sub.3                                                                             CH.sub.3                                                                              N                                   H                                                                                A-1                                                                               --                                                                                O  H                                                                                     ##STR182##  CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               --                                                                                O  H                                                                                     ##STR183##  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               --                                                                                O  H                                                                                     ##STR184##  Cl    OCH.sub.3                                                                             CH                                H  A-1                                                                               -- O  H      cyclobutyl  CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      cyclobutyl  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      cyclobutyl  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      cyclobutyl  CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      cyclobutyl  CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      cyclobutyl  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      cyclobutyl  Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.2CHCH.sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CH.sub.2CHCH.sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.2CHCH.sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.2CHCH.sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CH.sub.2CHCH.sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH.sub.2CHCH.sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH.sub.2CHCH.sub.2                                                                         Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CHCH.sub.2  CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CHCH.sub.2  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CHCH.sub.2  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CHCH.sub.2  CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CHCH.sub.2  CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CHCH.sub.2  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CHCH.sub.2  Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.2CFCH.sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CH.sub.2CFCH.sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CHFCH.sub.2 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CHFCH.sub.2 CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CHFCH.sub.2 CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CHFCH.sub.2 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH.sub.2 CHCHCH.sub.3                                                                      Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.2CCH CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CH.sub.2CCH CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.2CCH OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.2CCH CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CH.sub.2CCH CH.sub.3                                                                             OCH.sub. 3                                                                            N                                  H  A-1                                                                               -- O  H      CH.sub.2CCH OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH.sub.2CCH Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CCH         CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CCH         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CCH         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CCH         CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CCH         CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CCH         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CCCH.sub.2 F                                                                               Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CCCH.sub.2 F                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CCCH.sub.2 F                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CCCH.sub.2 F                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.2CCCH.sub.2 Cl                                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CH.sub.2CCCH.sub.2 Cl                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH.sub.2CCCH.sub.2 Cl                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CH.sub.2CCCH.sub.2 Cl                                                                      Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      OCH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      OCH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH.sub.3   Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      OCH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      OCH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH(CH.sub.3).sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      OCH.sub.2CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH.sub.2CH(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH.sub. 2CH(CH.sub.3).sub.2                                                               Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCF.sub.2 H CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      OCF.sub.2 H CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCF.sub.2 H OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCF.sub.2 H CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      OCF.sub.2 H CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCF.sub.2 H OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCF.sub.2 H Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Cl                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Cl                                                                      OCH.sub.3                                                                            OCH.sub. 3                                                                            N                                  H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Cl                                                                      Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 F                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 F                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 F                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 F                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 F                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 F                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 F                                                                       Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CF.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CF.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CF.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CF.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      OCH.sub.2 CF.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH.sub.2 CF.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH.sub.2 CF.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      OCF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCF.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      OCF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCF.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCF.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Cl                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Br                                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Br                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Br                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Br                                                                      Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2CCH                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      OCH.sub.2CCH                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2CCH                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2CCH                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      OCH.sub.2CCH                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH.sub.2CCH                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH.sub.2CCH                                                                               Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      OCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2CHCH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      OCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      OCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH.sub.2CHCH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      OCH.sub.2CHCH.sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      NO.sub.2    CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      NO.sub.2    CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      NO.sub.2    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      NO.sub.2    CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      NO.sub.2    CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      NO.sub.2    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      NO.sub.2    Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CH.sub.2 CH(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH(CH.sub.3).sub.2                                                                Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub. 2 CH.sub.2 F                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                               Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 OCH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 OCH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 OCH.sub.3                                                                Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               CH.sub.3                                                                             OCH.sub. 3                                                                            N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2CCH                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2CCH                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2CCH                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2CCH                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2CCH                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2CCH                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.2CCH                                                                       Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      N(CH.sub.3).sub.2                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      N(CH.sub.3).sub.2                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      N(CH.sub.3).sub.2                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      N(CH.sub.3).sub.2                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      N(CH.sub.3).sub.2                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      N(CH.sub.3).sub.2                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      N(CH.sub.3).sub.2                                                                          Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                              Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SCH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      SCH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SCH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SCH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      SCH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SCH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SCH.sub.3   Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SCH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      SCH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SCH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SCH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      SCH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SCH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SCH.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SCH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      SCH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SCH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SCH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      SCH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SCH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SCH.sub.2 CH.sub.2 CH.sub.3                                                                Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      SCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SCH.sub.2CHCH.sub. 2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      SCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SCH.sub.2CHCH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SCH.sub.2CHCH.sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SCH.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      SCH.sub.2CCH                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SCH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SCH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      SCH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SCH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SCH(CH.sub.3).sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SOCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      SOCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SOCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SOCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      SOCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SOCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SOCH.sub.3  Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SOCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      SOCH.sub. 2 CH.sub.3                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SOCH.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SOCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      SOCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SOCH.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SOCH.sub.2 CH.sub.3                                                                        Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.2 CH.sub.3                                                                 Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                               Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.3).sub.2                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.3).sub.2                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.3).sub.2                                                                 Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub. 2                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                      Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 NHCH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      SO.sub.2 NHCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 NHCH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 NHCH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      SO.sub.2 NHCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SO.sub.2 NHCH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SO.sub.2 NHCH.sub.3                                                                        Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CON(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CON(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CON(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CON(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CON(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CON(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CON(CH.sub.3).sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CONHCH.sub.3                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CONHCH.sub.3                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CONHCH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CONHCH.sub.3                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CONHCH.sub.3                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CONHCH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CONHCH.sub.3                                                                               Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CONHCH.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CON(CH.sub.2 CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CON(CH.sub.2 CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CON(CH.sub.2 CH.sub.3).sub.2                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H      CON(CH.sub.2 CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CON(CH.sub.2 CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H      CON(CH.sub.2 CH.sub.3).sub.2                                                               Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR185## CH.sub. 3                                                                            CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR186## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR187## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR188## CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H                                                                                      ##STR189## CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H                                                                                      ##STR190## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H                                                                                      ##STR191## Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR192## CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR193## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR194## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR195## CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H                                                                                      ##STR196## CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H                                                                                      ##STR197## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H                                                                                      ##STR198## Cl           CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR199## CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR200## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR201## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR202## CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H                                                                                      ##STR203## CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H                                                                                      ##STR204## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H                                                                                      ##STR205## Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR206## CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR207## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR208## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR209## CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H                                                                                      ##STR210## CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H                                                                                      ##STR211## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H                                                                                      ##STR212## Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR213## CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR214## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR215## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR216## CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H                                                                                      ##STR217## CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H                                                                                      ##STR218## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H                                                                                      ##STR219## Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR220## CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR221## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR222## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR223## CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H                                                                                      ##STR224## CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H                                                                                      ##STR225## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H                                                                                      ##STR226## Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR227## CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR228## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR229## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR230## CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H                                                                                      ##STR231## CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H                                                                                      ##STR232## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H                                                                                      ##STR233## Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR234## CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR235## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR236## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H                                                                                      ##STR237## CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  H                                                                                      ##STR238## CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H                                                                                      ##STR239## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  H                                                                                      ##STR240## Cl    OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CH.sub.3    CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CH.sub.3    CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CH.sub.3    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CH.sub.3    CH.sub.3                                                                             CH.sub. 3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CH.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CH.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CH(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CH(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CH(CH.sub.3).sub.2                                                                         Cl    OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CH.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CH.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CH(CH.sub.3)CH.sub.2 CH.sub.3                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CH(CH.sub.3)CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CH.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CH.sub.2 CH(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CH.sub.2 CH(CH.sub.3).sub.2                                                                Cl    OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      cyclopropyl CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      cyclopropyl CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      cyclopropyl OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      cyclopropyl CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      cyclopropyl CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      cyclopropyl OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      cyclopropyl Cl    OCH.sub.3                                                                             CH                                  CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR241##   CH.sub.3                                                                            CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR242##  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR243##  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR244##  CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR245##  CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR246##  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR247##  Cl    OCH.sub.3                                                                             CH                                  CH.sub.3                                                                         A-1                                                                               --                                                                                O  H                                                                                     ##STR248## CH.sub.3                                                                             CH.sub.3                                                                              CH                                  CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR249##  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR250##  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR251##  CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR252##  CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR253##  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR254##   Cl   OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR255##  CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR256##  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR257##  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR258##  CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR259##  CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR260##  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               --                                                                                O  H                                                                                     ##STR261##  Cl    OCH.sub.3                                                                             CH                                CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Cl                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Cl                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 Cl                                                                      Cl    OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 F                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 F                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 F                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub. 2 CH.sub.2 F                                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 F                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 F                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CH.sub.2 F                                                                       Cl    OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CF.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CF.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CF.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CF.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CF.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CF.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      OCH.sub.2 CF.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      OCF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      OCF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub. 3                                                                            CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      OCF.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      OCF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      OCF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      OCF.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      OCF.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      NO.sub.2    CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      NO.sub.2    CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      NO.sub.2    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      NO.sub.2    CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      NO.sub.2    CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      NO.sub.2    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      NO.sub.2    Cl    OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 Cl    OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        Cl    OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       Cl    OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CHCH.sub. 2                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               Cl    OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2CCH                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2CCH                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2CCH                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2CCH                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2CCH                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2CCH                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      CO.sub.2 CH.sub.2C CH                                                                      Cl    OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      N(CH.sub.3).sub.2                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      N(CH.sub.3).sub.2                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      N(CH.sub.3).sub.2                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  H      N(CH.sub.3).sub.2                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      N(CH.sub.3).sub.2                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      N(CH.sub.3).sub.2                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  H      N(CH.sub.3).sub.2                                                                          Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-F    CH.sub.3    CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  5-F    CH.sub.3    CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-F    CH.sub.3    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-F    CH.sub.3    CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  5-F    CH.sub.3    CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-F    CH.sub.3    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-F    CH.sub.3    Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-F    CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  5-F    CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-F    CH.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-F    CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  5-F    CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-F    CH.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-F    CH.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-F    CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  5-F    CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-F    CH(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-F    CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  5-F    CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-F    CH(CH.sub.3 ).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-F    CH(CH.sub.3).sub.2                                                                         Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-F    CH.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  5-F    CH.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-F    CH(CH.sub.3)CH.sub.2 CH.sub.3                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-F    CH(CH.sub.3)CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  5-F    CH.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-F    CH.sub.2 CH(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-F    CH.sub.2 CH(CH.sub.3).sub.2                                                                Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-Cl   cyclopropyl CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  5-Cl   cyclopropyl CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-Cl   cyclopropyl OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-Cl   cyclopropyl CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  5-Cl   cyclopropyl CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-Cl   cyclopropyl OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-Cl   cyclopropyl Cl    OCH.sub.3                                                                             CH                                  H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR262##  CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR263##  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR264##  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR265##  CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR266##  CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR267##  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR268##  Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR269##  CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR270##  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR271##  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR272##  CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR273##  CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               --                                                                                 O                                                                                5-Cl                                                                                  ##STR274##  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR275##  Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR276##  CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR277##  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR278##  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR279##  CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR280##  CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR281##  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               --                                                                                O  5-Cl                                                                                  ##STR282##  Cl    OCH.sub.3                                                                             CH                                H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub. 2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Cl                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Br                                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Br                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Br                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Br                                                                      Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2CCH                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2CCH                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2CCH                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2C CH                                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2CCH                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2CCH                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2CCH                                                                               Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                        Cl    OCH.sub. 3                                                                            CH                                 H  A-1                                                                               -- O  5-OCH.sub.3                                                                           NO.sub.2    CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  5-OCH.sub.3                                                                           NO.sub.2    CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.3                                                                           NO.sub.2    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.3                                                                           NO.sub.2    CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  5-OCH.sub.3                                                                           NO.sub.2    CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-OCH.sub.3                                                                           NO.sub.2    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-OCH.sub.3                                                                           NO.sub.2    Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub. 3                                                                 CO.sub.2 CH(CH.sub.3).sub.2                                                                Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                               Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                                Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  4-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  4-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  4-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  4-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  4-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  4-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  4-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  4-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  4-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  4-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  4-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  4-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  4-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  4-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  4-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  4-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  4-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  4-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  4-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  4-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  4-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                 Cl    OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  4-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  4-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  4-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  4-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                  H  A-1                                                                               -- O  4-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  4-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  H  A-1                                                                               -- O  4-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  5-F    SCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  5-F    SCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  5-F    SCH.sub.2CHCH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  5-F    SCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               -- O  5-F    SCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub. 3                                                                         A-1                                                                               -- O  5-F    SCH.sub.2CHCH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  5-F    SCH.sub.2CHCH.sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  5-F    SCH.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  5-F    SCH.sub.2CCH                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  5-F    SCH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  5-F    SCH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               -- O  5-F    SCH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  5-F    SCH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  5-F    SCH(CH.sub.3).sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  5-F    SOCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  5-F    SOCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  5-F    SOCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  5-F    SOCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               -- O  5-F    SOCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  5-F    SOCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  5-F    SOCH.sub.3  Cl    OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  5-F    SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                 CH.sub.3                                                                          A-1                                                                               -- O  5-F    SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  5-F    SO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                 CH.sub.3                                                                          A-1                                                                               -- O  5-F    SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                  CH.sub.3                                                                          A-1                                                                               -- O  5-F    SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  5-F    SO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                  CH.sub.3                                                                          A-1                                                                               -- O  5-F    SO.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                 __________________________________________________________________________     R   A    E   W   R.sub.1                                                                             R.sub.2   X.sub.1 Y.sub.1                                                                              m.p. (°C.)                __________________________________________________________________________     H   A-2  --  O   H    CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                               O                                      H   A-2  --  O   H    CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                               CH.sub.2                               H   A-2  --  O   H    CO.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                              O                                      H   A-2  --  O   H    CO.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                              CH.sub.2                               H   A-2  --  O   H    CO.sub.2 CH.sub.3                                                                        OCH.sub.2 CH.sub.3                                                                     O                                      H   A-2  --  O   H    CO.sub.2 CH.sub.3                                                                        OCF.sub.2 H                                                                            CH.sub.2                               H   A-2  --  O   H    CO.sub.2 SO.sub.2 N(CH.sub.3).sub.2                                                      CH.sub.3                                                                               O                                      H   A-2  --  O   H    SO.sub.2 N(CH.sub.3).sub.2                                                               OCH.sub.3                                                                              O                                      H   A-2  --  O   H    SO.sub.2 N(CH.sub.3).sub.2                                                               OCF.sub.2 H                                                                            CH.sub.2                               H   A-3  --  O   H    CO.sub.2 CH.sub.3                                                                        CH.sub.3                                       H   A-3  --  O   H    CO.sub.2 CH.sub.3                                                                        OCH.sub.3                                      H   A-3  --  O   H    CO.sub.2 CH.sub.3                                                                        OCH.sub.2 CH.sub.3                             H   A-3  --  O   H    CO.sub.2 CH.sub.3                                                                        OCF.sub.2 H                                    H   A-3  --  O   H    Cl        CH.sub.3                                       H   A-3  --  O   H    Cl        OCH.sub.3                                      H   A-3  --  O   H    SO.sub.2 CH.sub.3                                                                        CH.sub.3                                       H   A-3  --  O   H    SO.sub.2 CH.sub.3                                                                        OCH.sub.3                                      __________________________________________________________________________     R   A    E   W   R.sub.1                                                                             R.sub.2   X.sub.1 Y.sub.3                                                                              m.p. (°C.)                __________________________________________________________________________     H   A-4  --  O   H    CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                               H                                      H   A-4  --  O   H    CO.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                              H                                      H   A-4  --  O   H    CO.sub.2 CH.sub.3                                                                        OCH.sub.2 CH.sub.3                                                                     H                                      H   A-4  --  O   H    CO.sub.2 CH.sub.3                                                                        OCF.sub.2 H                                                                            H                                      H   A-4  --  O   H    CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                               CH.sub.3                               H   A-4  --  O   H    CO.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                              CH.sub.3                               H   A-4  --  O   H    CO.sub.2 CH.sub.3                                                                        OCF.sub.2 H                                                                            CH.sub.3                               __________________________________________________________________________     R   A    E   W   R.sub.1                                                                             R.sub.2   X.sub.2 Y.sub.2                                                                              m.p. (°C.)                __________________________________________________________________________     H   A-5  --  O   H    CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                               OCH.sub.3                              H   A-5  --  O   H    CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                               OCH.sub.2 CH.sub.3                     H   A-5  --  O   H    CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                               SCH.sub.3                              H   A-5  --  O   H    CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                               SCH.sub.2 CH.sub.3                     H   A-5  --  O   H    CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                               CH.sub.3                               H   A-5  --  O   H    CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                               CH.sub.2 CH.sub.3                      H   A-5  --  O   H    CO.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                      OCH.sub.3                              H   A-5  --  O   H    CO.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                      SCH.sub.3                              H   A-5  --  O   H    CO.sub.2 CH.sub.3                                                                        CH.sub.2 CH.sub.3                                                                      OCH.sub.2 CH.sub.3                     H   A-5  --  O   H    CO.sub.2 CH.sub.3                                                                        CH.sub.2 CF.sub.3                                                                      OCH.sub.3                              __________________________________________________________________________     R   A    E   W   R.sub.1                                                                             R.sub.2   X.sub.3       m.p. (°C.)                __________________________________________________________________________     H   A-6  --  O   H    CO.sub.2 CH.sub.3                                                                        CH.sub.3                                       H   A-6  --  O   H    CO.sub.2 CH.sub.3                                                                        OCH.sub.3                                      H   A-6  --  O   H    NO.sub.2  CH.sub.3                                       H   A-6  --  O   H    NO.sub.2  OCH.sub.3                                      __________________________________________________________________________     R   A    E   W   R.sub.1                                                                             R.sub.2   X.sub.4 Y.sub.4                                                                              m.p. (°C.)                __________________________________________________________________________     H   A-7  --  O   H    CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                               CH.sub.3                               H   A-7  --  O   H    CO.sub.2 CH.sub. 3                                                                       CH.sub.3                                                                               OCH.sub.3                              H   A-7  --  O   H    CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                               OCH.sub.2 CH.sub.3                     H   A-7  --  O   H    CO.sub.2 CH.sub.3                                                                        CH.sub.3                                                                               Cl                                     H   A-7  --  O   H    CO.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                              CH.sub.3                               H   A-7  --  O   H    CO.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                              OCH.sub.3                              H   A-7  --  O   H    CO.sub.2 CH.sub.3                                                                        OCH.sub.2 CH.sub.3                                                                     OCH.sub.3                              __________________________________________________________________________                                                     m.p.                           R  A  E  W  R.sub.1                                                                               R.sub.2     X     Y      Z   (°C.)                   __________________________________________________________________________     H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                    CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCF.sub.2 H                                                                           CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             SCF.sub.2 H                                                                           CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             SCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                    CH                                 H  A-1                                                                               -- O  H      CO.sub. 2 CH.sub.3                                                                         CH.sub.3                                                                             NHCH.sub.3                                                                            N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             N(CH.sub.3).sub.2                                                                     N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.2 F                                                                            CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CCH    CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             cyclopropyl                                                                           CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CN     CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                     CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                    CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            SCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCF.sub.2 H                                                                           CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.2 F                                                                            CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                     N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub. 3                                                                         OCH.sub.3                                                                            NHCH.sub.3                                                                            N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            CN     CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          OCF.sub.2 H                                                                          CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          OCF.sub.2 H                                                                          OCH.sub.2 CH.sub.3                                                                    CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          OCF.sub.2 H                                                                          CH.sub.2 CH.sub.3                                                                     CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          OCF.sub.2 H                                                                          CH.sub.2 F                                                                            CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          OCF.sub.2 H                                                                          SCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          OCF.sub.2 H                                                                          N(CH.sub.3).sub.2                                                                     CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          OCF.sub.2 H                                                                          NHCH.sub.3                                                                            CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.2 OCH.sub.3                                                                   OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.2 OCH.sub.3                                                                   OCH.sub.2 CH.sub.3                                                                    CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.2 OCH.sub.3                                                                   CH.sub.3                                                                              CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.2 OCH.sub.3                                                                   CH.sub.2 F                                                                            CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.2 OCH.sub.3                                                                   CH.sub.2 Cl                                                                           CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CH.sub.2 OCH.sub.3                                                                   CH.sub.2 Br                                                                           CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          SCF.sub.2 H                                                                          OCH.sub.2 CH.sub.3                                                                    CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          SCF.sub.2 H                                                                          CH.sub.2 CH.sub.3                                                                     CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          SCF.sub.2 H                                                                          CH.sub.2 F                                                                            CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          SCF.sub.2 H                                                                          NHCH.sub.3                                                                            N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          N(CH.sub.3).sub.2                                                                    OCH.sub.2 CH.sub.3                                                                    N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          N(CH.sub.3).sub.2                                                                    CH.sub.2 CH.sub.3                                                                     N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          N(CH.sub.3).sub.2                                                                    CH.sub.2 F                                                                            N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          N(CH.sub.3).sub.2                                                                    CH.sub.2 OCH.sub.3                                                                    N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          N(CH.sub.3).sub.2                                                                    cyclopropyl                                                                           N                                  H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CCH   CH.sub.2 CH.sub.3                                                                     CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CCH   OCH.sub.3                                                                             CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CCH   N(CH.sub.3).sub.2                                                                     CH                                 H  A-1                                                                               -- O  H      CO.sub.2 CH.sub.3                                                                          CCH   OCH.sub.2 CH.sub.3                                                                    N                                  __________________________________________________________________________

                                      TABLE III                                    __________________________________________________________________________     R  A  E W R.sub.1                                                                               R.sub.2     X     Y      Z  m.p.(°C.)                  __________________________________________________________________________     H  A-1                                                                               --                                                                               O H      H           CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      H           CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      H           OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      H           CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      H           CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      H           OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      H           Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      Cl          CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      Cl          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      Cl          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      Cl          CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      Cl          CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      Cl          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      Cl          Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      Br          CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      Br          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      Br          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      Br          CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      Br          CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      Br          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      Br          Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      F           CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      F           CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      F           OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      F           CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      F           CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      F           OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      F           Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.3    CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.3    CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.3    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.3    CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CH.sub.3    CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH.sub.3    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH.sub.3    Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                         Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH.sub.2 CH.sub.3                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH(CH.sub.3).sub.2                                                                Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2 Cl CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2 Cl CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2 Cl OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2 Cl CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 Br CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 Br OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 F  Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                             CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                             CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                             CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                             Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                              Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                     Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CF.sub.2 H  CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CF.sub.2 H  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CF.sub.2 H  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CF.sub.2 H  CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 H  CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 H  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 H  Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CCl.sub.2 H CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CCl.sub.2 H CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CCl.sub.2 H OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CCl.sub.2 H CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CCl.sub.2 H CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CCl.sub.2 H OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CCl.sub.2 H Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2 CH(F)CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2 CH(F)CH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2 CH(F)CH.sub.3                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH(Cl)CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH(Cl)CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH.sub.2 Br                                                                    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH.sub.2 Br                                                                    Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      cyclopropyl CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      cyclopropyl CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      cyclopropyl OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      cyclopropyl CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      cyclopropyl CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      cyclopropyl OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      cyclopropyl Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR283##  CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR284##  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR285##  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR286##  CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR287##  CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR288##  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR289##  Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR290##  CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR291##  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR292##  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR293##  CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR294##  CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR295##  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR296##  Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR297##  CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H   A-1                                                                              --                                                                               O                                                                                H                                                                                     ##STR298##  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR299##  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR300##  CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR301##  CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR302##  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR303##  Cl    OCH.sub.3                                                                             CH                                  H  A-1                                                                               --                                                                               O H      cyclobutyl  CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      cyclobutyl  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      cyclobutyl  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      cyclobutyl  CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      cyclobutyl  CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      cyclobutyl  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      cyclobutyl  Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                         Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CHCH.sub.2  CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CHCH.sub.2  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CHCH.sub.2  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CHCH.sub.2  CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CHCH.sub.2  CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CHCH.sub.2  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CHCH.sub.2  Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2CFCH.sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2CFCH.sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CHFCH.sub.2 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CHFCH.sub.2 CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CHFCH.sub.2 CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CHFCH.sub.2 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CCHCH.sub.3                                                                        Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2CCH CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2CCH CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2CCH OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2CCH CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CCH CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CCH OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CCH Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CCH         CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      C CH        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CCH         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CCH         CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CCH         CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CCH         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CCCH.sub.2 F                                                                               Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CCCH.sub.2 F                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CCCH.sub.2 F                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CCCH.sub.2 F                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CH.sub.2CCCH.sub.2 Cl                                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CCCH.sub.2 Cl                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CCCH.sub.2 Cl                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CCCH.sub.2 Cl                                                                      Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.3   Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CH(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CH(CH.sub.3).sub.2                                                                Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCF.sub.2 H CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      OCF.sub.2 H CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCF.sub.2 H OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCF.sub.2 H CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 H CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 H OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 H Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                      Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                       Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Br                                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Br                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Br                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Br                                                                      Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2CCH                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2CCH                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2CCH                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2CCH                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2C CH                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CCH                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CCH                                                                               Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      NO.sub.2    CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      NO.sub.2    CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      NO.sub.2    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      NO.sub.2    CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      NO.sub.2    CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      NO.sub.2    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      NO.sub.2    Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                                Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                               Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                                Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2C CH                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                       Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                          Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                              Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SCH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      SCH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SCH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SCH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      SCH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SCH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SCH.sub.3   Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                                Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 OCH.sub. 3                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      SCH.sub.2CCH                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SCH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SCH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      SCH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SCH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SCH(CH.sub.3).sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SOCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      SOCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SOCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SOCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.3  Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                        Cl    OCH.sub. 3                                                                            CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                 Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                               Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub. 3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                 Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        OCH.sub.3                                                                            OCH.sub. 3                                                                            N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                        Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                      Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                        Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                              Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                        CH.sub. 3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                               Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CONHCH.sub.2 CH.sub.3                                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CON(CH.sub.2 CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CON(CH.sub.2 CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CON(CH.sub.2 CH.sub.3).sub.2                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.2 CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.2 CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.2 CH.sub.3).sub.2                                                               Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR304## CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR305## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR306## OCH.sub. 3                                                                           OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR307## CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR308## CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR309## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR310## Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR311## CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR312## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR313## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR314## CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR315## CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR316## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR317## Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR318## CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR319## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR320## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR321## CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR322## CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR323## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR324## Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR325## CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR326## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR327## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR328## CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR329## CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR330## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR331## Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR332## CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR333## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR334## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR335## CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR336## CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR337## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR338## Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR339## CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR340## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR341## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR342## CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR343## CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR344## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR345## Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR346## CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR347## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR348## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR349## CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR350## CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR351## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR352## Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR353## CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR354## CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR355## OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H                                                                                      ##STR356## CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR357## CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR358## OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR359## Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.3    CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.3    CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub. 3   OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.3    CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.3    CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.3    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.3    Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                         CH.sub. 3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                         Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH.sub.2 CH.sub.3                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH(CH.sub.3).sub.2                                                                Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR360##  CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR361##  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR362##  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR363##  CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR364##  CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR365##  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR366##  Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR367##  CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR368##  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR369##  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR370##  CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR371##  CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR372##  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR373##  Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR374##  CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR375##  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR376##  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR377##  CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR378##  CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR379##  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O                                                                                H                                                                                     ##STR380##  Cl    OCH.sub.3                                                                             CH                                  CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                      Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                       Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2    CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2    CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2    CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2    CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2    Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub. 3                                                                            N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                 Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                       Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                               Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2C CH                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                       Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                          Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-F    CH.sub.3    CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 2-F    CH.sub.3    CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-F    CH.sub.3    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-F    CH.sub.3    CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 2-F    CH.sub.3    CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-F    CH.sub.3    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-F    CH.sub.3    Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-F    CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 2-F    CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-F    CH.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-F    CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 2-F    CH.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-F    CH.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-F    CH.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-F    CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 2-F    CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-F    CH(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-F    CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 2-F    CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-F    CH(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-F    CH(CH.sub.3).sub.2                                                                         Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-F    CH.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 2-F    CH.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-F    CH(CH.sub.3)CH.sub.2 CH.sub.3                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-F    CH(CH.sub.3)CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 2-F    CH.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-F    CH.sub.2 CH(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-F    CH.sub.2 CH(CH.sub.3).sub.2                                                                Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-Cl   cyclopropyl CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 2-Cl   cyclopropyl CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-Cl   cyclopropyl OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-Cl   cyclopropyl CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 2-Cl   cyclopropyl CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-Cl   cyclopropyl OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-Cl   cyclopropyl Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O                                                                                2-Cl                                                                                  ##STR381##  CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O                                                                                2-Cl                                                                                  ##STR382##  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O                                                                                2-Cl                                                                                  ##STR383##  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O                                                                                2-Cl                                                                                  ##STR384##  CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O                                                                                 2-Cl                                                                                 ##STR385##  CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O                                                                                2-Cl                                                                                  ##STR386##  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O                                                                                2-Cl                                                                                  ##STR387##  Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O                                                                                2-Cl                                                                                  ##STR388##  CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O                                                                                2-Cl                                                                                  ##STR389##  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O                                                                                2-Cl                                                                                  ##STR390##  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O                                                                                2-Cl                                                                                  ##STR391##  CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O                                                                                2-Cl                                                                                  ##STR392##  CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O                                                                                2-Cl                                                                                  ##STR393##  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O                                                                                2-Cl                                                                                  ##STR394##  Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O                                                                                2-Cl                                                                                  ##STR395##  CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O                                                                                2-Cl                                                                                  ##STR396##  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H   A-1                                                                              --                                                                               O                                                                                2-Cl                                                                                  ##STR397##  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O                                                                                2-Cl                                                                                  ##STR398##  CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O                                                                                2-Cl                                                                                  ##STR399##  CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O                                                                                2-Cl                                                                                  ##STR400##  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O                                                                                2-Cl                                                                                  ##STR401##  Cl    OCH.sub.3                                                                             CH                                  H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub. 2 CH.sub.2 F                                                             CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                              Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Cl                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Cl                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Br                                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Br                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Br                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Br                                                                      Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CCH                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CCH                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CCH                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CCH                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CCH                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CCH                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CCH                                                                               Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 6-CH.sub.3                                                                            OCH.sub.2CHCH.sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           NO.sub.2    CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           NO.sub.2    CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           NO.sub.2    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           NO.sub.2    CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           NO.sub.2    CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           NO.sub.2    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           NO.sub.2    Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                        Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                                Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                              Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                               Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 2-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                                Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                 Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                 CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                 Cl    OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SCH.sub.2CHCH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SCH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SCH.sub.2CHCH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SCH.sub.2CHCH.sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SCH.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SCH.sub.2CCH                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SCH(CH.sub.3).sub.2                                                                        OCH.sub. 3                                                                           OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SCH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SCH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SCH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SCH(CH.sub.3).sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SOCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SOCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SOCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SOCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SOCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SOCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SOCH.sub.3  Cl    OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                   CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.3                                                                              N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 2-F    SO.sub.2 CH.sub.3                                                                          Cl    OCH.sub.3                                                                             CH                                   __________________________________________________________________________     R     A    E   W   R.sub.1                                                                            R.sub.2 X.sub.1                                                                               Y.sub.1                                                                             m.p.(°C.)                    __________________________________________________________________________     H     A-2  --  O   H   CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                              O                                        H     A-2  --  O   H   CO.sub.2 CH.sub.3                                                                      CH.sub.3                                                                              CH.sub.2                                 H     A-2  --  O   H   CO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                             O                                        H     A-2  --  O   H   CO.sub.2 CH.sub.3                                                                      OCH.sub.3                                                                             CH.sub.2                                 H     A-2  --  O   H   CO.sub.2 CH.sub.3                                                                      OCH.sub.2 CH.sub.3                                                                    O                                        H     A-2  --  O   H   CO.sub.2 CH.sub.3                                                                      OCF.sub.2 H                                                                           CH.sub.2                                 H     A-2  --  O   H   SO.sub.2 N(CH.sub.3).sub.2                                                             CH.sub.3                                                                              O                                        H     A-2  --  O   H   SO.sub.2 N(CH.sub.3).sub.2                                                             OCH.sub.3                                                                             O                                        H     A-2  --  O   H   SO.sub.2 N(CH.sub.3).sub.2                                                             OCF.sub.2 H                                                                           CH.sub.2                                 __________________________________________________________________________     R       A     E   W    R.sub.1                                                                             R.sub.2                                                                               X.sub.1 m.p.(°C.)                    __________________________________________________________________________     H       A-3   --  O    H    CO.sub.2 CH.sub.3                                                                     CH.sub.3                                    H       A-3   --  O    H    CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                   H       A-3   --  O    H    CO.sub.2 CH.sub.3                                                                     OCH.sub.2 CH.sub.3                          H       A-3   --  O    H    CO.sub.2 CH.sub.3                                                                     OCF.sub.2 H                                 H       A-3   --  O    H    Cl     CH.sub.3                                    H       A-3   --  O    H    Cl     OCH.sub.3                                   H       A-3   --  O    H    SO.sub.2 CH.sub.3                                                                     CH.sub.3                                    H       A-3   --  O    H    SO.sub.2 CH.sub.3                                                                     OCH.sub.3                                   __________________________________________________________________________     R     A    E   W   R.sub.1                                                                            R.sub.2                                                                               X.sub.1 Y.sub.3                                                                             m.p.(°C.)                    __________________________________________________________________________     H     A-4  --  O   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                               H                                        H     A-4  --  O   H   CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                              H                                        H     A-4  --  O   H   CO.sub.2 CH.sub.3                                                                     OCH.sub.2 CH.sub.3                                                                     H                                        H     A-4  --  O   H   CO.sub.2 CH.sub.3                                                                     OCF.sub.2 H                                                                            H                                        H     A-4  --  O   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                               CH.sub.3                                 H     A-4  --  O   H   CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                              CH.sub.3                                 H     A-4  --  O   H   CO.sub.2 CH.sub.3                                                                     OCF.sub.2 H                                                                            CH.sub.3                                 __________________________________________________________________________     R     A    E   W   R.sub.1                                                                            R.sub.2                                                                               X.sub.2                                                                              Y.sub.2                                                                               m.p.(°C.)                    __________________________________________________________________________     H     A-5  --  O   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.3                                  H     A-5  --  O   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             OCH.sub.2 CH.sub.3                         H     A-5  --  O   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             SCH.sub.3                                  H     A-5  --  O   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             SCH.sub.2 CH.sub.3                         H     A-5  --  O   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.3                                   H     A-5  --  O   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                             CH.sub.2 CH.sub.3                          H     A-5  --  O   H   CO.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                  H     A-5  --  O   H   CO.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                    SCH.sub.3                                  H     A-5  --  O   H   CO.sub.2 CH.sub.3                                                                     CH.sub.2 CH.sub.3                                                                    OCH.sub.2 CH.sub.3                         H     A-5  --  O   H   CO.sub.2 CH.sub.3                                                                     CH.sub.2 CF.sub.3                                                                    OCH.sub.3                                  __________________________________________________________________________     R      A     E    W    R.sub.1                                                                             R.sub.2 X.sub.3                                                                               m.p.(°C.)                    __________________________________________________________________________     H      A-6   --   O    H    CO.sub.2 CH.sub.3                                                                      CH.sub.3                                   H      A-6   --   O    H    CO.sub.2 CH.sub.3                                                                      OCH.sub.3                                  H      A-6   --   O    H    NO.sub.2                                                                               CH.sub.3                                   H      A-6   --   O    H    NO.sub.2                                                                               OCH.sub.3                                  __________________________________________________________________________     R    A    E   W   R.sub.1                                                                            R.sub.2                                                                               X.sub.4                                                                               Y.sub.4                                                                               m.p.(°C.)                    __________________________________________________________________________     H    A-7  --  O   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                              CH.sub.3                                   H    A-7  --  O   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                              OCH.sub.3                                  H    A-7  --  O   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                              OCH.sub.2 CH.sub.3                         H    A-7  --  O   H   CO.sub.2 CH.sub.3                                                                     CH.sub.3                                                                              Cl                                         H    A-7  --  O   H   CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                             CH.sub.3                                   H    A-7  --  O   H   CO.sub.2 CH.sub.3                                                                     OCH.sub.3                                                                             OCH.sub.3                                  H    A-7  --  O   H   CO.sub.2 CH.sub.3                                                                     OCH.sub.2 CH.sub.3                                                                    OCH.sub.3                                  __________________________________________________________________________     R  A  E W R.sub.1                                                                               R.sub.2     X     Y      Z  m.p.(°C.)                  __________________________________________________________________________     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                    CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             OCF.sub.2 H                                                                           CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             SCF.sub.2 H                                                                           CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             SCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                    N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             NHCH.sub.3                                                                            N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             N(CH.sub.3).sub.2                                                                     N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CH.sub.2 F                                                                            CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CCH    CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             cyclopropyl                                                                           CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.3                                                                             CN     CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                     CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                    N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            SCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            OCF.sub.2 H                                                                           CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            CH.sub.2 F                                                                            CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                     N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            NHCH.sub.3                                                                            N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          OCH.sub.3                                                                            CN     CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          OCF.sub. 2 H                                                                         CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          OCF.sub.2 H                                                                          OCH.sub.2 CH.sub.3                                                                    CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          OCF.sub.2 H                                                                          CH.sub.2 CH.sub.3                                                                     N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          OCF.sub.2 H                                                                          CH.sub.2 F                                                                            N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          OCF.sub.2 H                                                                          SCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          OCF.sub.2 H                                                                          N(CH.sub.3).sub.2                                                                     CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          OCF.sub.2 H                                                                          NHCH.sub.3                                                                            N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.2 OCH.sub.3                                                                   OCH.sub.3                                                                             N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.2 OCH.sub.3                                                                   OCH.sub.2 CH.sub.3                                                                    CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.2 OCH.sub.3                                                                   CH.sub.3                                                                              CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.2 OCH.sub.3                                                                   CH.sub.2 F                                                                            CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.2 OCH.sub.3                                                                   CH.sub.2 Cl                                                                           CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CH.sub.2 OCH.sub.3                                                                   CH.sub.2 Br                                                                           N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          SCF.sub.2 H                                                                          OCH.sub.2 CH.sub.3                                                                    CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          SCF.sub.2 H                                                                          CH.sub.2 CH.sub.3                                                                     CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          SCF.sub.2 H                                                                          CH.sub.2 F                                                                            CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          SCF.sub.2 H                                                                          NHCH.sub.3                                                                            N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          N(CH.sub.3).sub.2                                                                    OCH.sub.2 CH.sub.3                                                                    N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          N(CH.sub.3).sub.2                                                                    CH.sub.2 CH.sub.3                                                                     N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          N(CH.sub.3).sub.2                                                                    CH.sub.2 F                                                                            CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          N(CH.sub.3).sub.2                                                                    CH.sub.2 OCH.sub.3                                                                    N                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          N(CH.sub.3).sub.2                                                                    cyclopropyl                                                                           CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CCH   CH.sub.2 CH.sub.3                                                                     CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CCH   OCH.sub.3                                                                             CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CCH   N(CH.sub.3).sub.2                                                                     CH                                   H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                          CCH   OCH.sub.2 CH.sub.3                                                                    CH                                   __________________________________________________________________________

                                      TABLE IV                                     __________________________________________________________________________     R  A  E W R.sub.1                                                                               R.sub.2    X     Y      Z  m.p. (°C.)                  __________________________________________________________________________     H  A-1                                                                               --                                                                               O H      H          CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      H          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      H          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      H          CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      H          CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      H          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      H          Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      Cl         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      Cl         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      Cl         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      Cl         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      Cl         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      Cl         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      Cl         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      Br         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      Br         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      Br         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      Br         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      Br         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      Br         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      Br         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      F          CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      F          CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      F          OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      F          CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      F          CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      F          OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      F          Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.3   Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH.sub.2 CH.sub.3                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH.sub.2 CH.sub.3                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2 CH(CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2 CH(CH.sub.3).sub.2                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 Cl                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 Cl                                                                               CH.sub. 3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 Cl                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 Cl                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2 Br                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2 Br                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2 F Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                            CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                            CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                            OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(Cl)CH.sub.3                                                                            Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                             CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                             CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub. 3                                                                            CH                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                             CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.3                                                                             Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                    CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                    OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(F)CH.sub.2 CH.sub.3                                                                    Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub. 3                                                                            CH                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CF.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 H CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 H CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 H OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CF.sub.2 H CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CF.sub.2 H CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CF.sub.2 H OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CF.sub.2 H Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CCl.sub.2 H                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CCl.sub.2 H                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CCl.sub.2 H                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CCl.sub.2 H                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CCl.sub.2 H                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CCl.sub.2 H                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CCl.sub.2 H                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH(F)CH.sub.3                                                                    CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH(F)CH.sub.3                                                                    CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2 CH(F)CH.sub.3                                                                    OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH(Cl)CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH(Cl)CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH.sub.2 Br                                                                   OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH.sub.2 Br                                                                   Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      cyclopropyl                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      cyclopropyl                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      cyclopropyl                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      cyclopropyl                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      cyclopropyl                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      cyclopropyl                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      cyclopropyl                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR402##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR403##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR404##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR405##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR406##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR407##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR408##                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR409##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR410##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR411##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR412##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR413##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR414##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR415##                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR416##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR417##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR418##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR419##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR420##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR421##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR422##                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      cyclobutyl CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      cyclobutyl CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      cyclobutyl OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      cyclobutyl CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      cyclobutyl CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      cyclobutyl OCH.sub. 3                                                                           OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      cyclobutyl Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CHCH.sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CHCH.sub.2 CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CHCH.sub.2 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CHCH.sub.2 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CHCH.sub.2 CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CHCH.sub.2 CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CHCH.sub.2 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CHCH.sub.2 Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CFCH.sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CFCH.sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CHFCH.sub.2                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CHFCH.sub.2                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CHFCH.sub.2                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CHFCH.sub.2                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CCHCH.sub.3                                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CCH                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CCH                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CCH                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CCH                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CCH                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CCH                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CCH                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CCH        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CCH        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CCH        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CCH        CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CCH        CH.sub. 3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CCH        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CCCH.sub.2 F                                                                              Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CCCH.sub.2 F                                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CCCH.sub.2 F                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CCCH.sub.2 F                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CH.sub.2CCCH.sub.2 Cl                                                                     CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CCCH.sub.2 Cl                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CCCH.sub.2 Cl                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CH.sub.2CCCH.sub.2 Cl                                                                     Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.3  Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.3                                                                        Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH(CH.sub.3).sub.2                                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CH(CH.sub.3).sub.2                                                               CH.sub. 3                                                                            CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2CH(CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2CH(CH.sub.3).sub.2                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 H                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 H                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 H                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 H                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCF.sub.2 H                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCF.sub.2 H                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCF.sub.2 H                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Br                                                                     CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Br                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Br                                                                     OCH.sub.3                                                                            OCH.sub. 3                                                                            N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Br                                                                     Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CCH                                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CCH                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CCH                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CCH                                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2CCH                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2CCH                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2CCH                                                                              Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      OCH.sub.2CHCH.sub.2                                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      NO.sub.2   CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      NO.sub.2   CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      NO.sub.2   OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      NO.sub.2   CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      NO.sub.2   CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      NO.sub.2   OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      NO.sub.2   Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub. 2 CH.sub.3                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3 ).sub.2                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH(CH.sub.3).sub.2                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 F                                                              Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 OCH.sub.3                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub. 2 CH.sub.2 CHCH.sub.2                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2C CH                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      OCH.sub.3                                                                            CH                                           H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                             CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                             CH.sub.3                                                                             OCH.sub. 3                                                                            CH                                    H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                             CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      NCH.sub.2 CH.sub.3 (CH.sub.3)                                                             Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.3  CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.3  CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.3  OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.3  Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.3                                                                        Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 CH.sub.3                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH.sub.2CHCH.sub.2                                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2 CH.sub.2 OCH.sub.3                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SCH.sub.2CCH                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH(CH.sub.3).sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SCH(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SCH(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH(CH.sub.3).sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SCH(CH.sub.3).sub.2                                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.3 CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.3 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.3 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.3 CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SOCH.sub.3 CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SOCH.sub.3 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SOCH.sub.3 Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.3                                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.3                                                                Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SOCH.sub.2 CH.sub.2 CH.sub.3                                                              Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.2 CH.sub.3).sub.2                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     OCH.sub.3                                                                            OCH.sub. 3                                                                            CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3)CH.sub.2 CH.sub.3                                                     Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 NHCH.sub.3                                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      SO.sub.2 N(OCH.sub.3)CH.sub.3                                                             Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CON(CH.sub.3).sub.2                                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CONHCH.sub.3                                                                              Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.2 CH.sub.3).sub.2                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.2 CH.sub.3).sub.2                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.2 CH.sub.3).sub.2                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CON(CH.sub.2 CH.sub.3).sub.2                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CON(CH.sub.2 CH.sub.3).sub.2                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CON(CH.sub.2 CH.sub.3).sub.2                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CON(CH.sub.2 CH.sub.3).sub.2                                                              Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR423##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR424##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR425##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR426##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR427##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR428##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR429##                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR430##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR431##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR432##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR433##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR434##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR435##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR436##                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR437##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR438##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR439##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR440##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR441##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR442##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR443##                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR444##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR445##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR446##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR447##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR448##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR449##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR450##                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR451##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR452##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR453##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR454##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR455##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR456##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR457##                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR458##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR459##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR460##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR461##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR462##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR463##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR464##                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR465##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR466##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR467##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR468##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR469##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR470##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR471##                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR472##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR473##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR474##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H                                                                                      ##STR475##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR476##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR477##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H                                                                                      ##STR478##                                                                               Cl    OCH.sub.3                                                                             CH                                    CH.sub. 3                                                                         A-1                                                                               --                                                                               O H      CH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.3   Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub. 2 CH.sub.3                                                                        Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3).sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH.sub.2 CH.sub.3                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH(CH.sub.3)CH.sub.2 CH.sub.3                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH(CH.sub. 3).sub.2                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH(CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CH.sub.2 CH(CH.sub.3).sub.2                                                               Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      cyclopropyl                                                                               Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR479##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR480##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR481##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR482##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR483##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR484##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR485##                                                                               Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR486##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR487##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR488##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR489##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR490##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR491##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR492##                                                                               Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR493##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR494##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR495##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR496##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR497##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR498##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H                                                                                      ##STR499##                                                                               Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 Cl                                                                     Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CH.sub.2 F                                                                      Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCH.sub.2 CF.sub.3                                                                        Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3 Cl                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      OCF.sub.2 CH.sub.3                                                                        Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2   CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2   CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2   OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2   CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2   CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2   OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      NO.sub.2   Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub. 3                                                                         A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.3                                                                Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CH.sub.2 OCH.sub.3                                                      Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub. 2 CH.sub.2 CHCH.sub.2                                                             CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2 CHCH.sub.2                                                              Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2C CH                                                                     CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.2CCH                                                                      Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O H      N(CH.sub.3).sub.2                                                                         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-F    CH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 5-F    CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-F    CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-F    CH.sub.3   CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 5-F    CH.sub.3   CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-F    CH.sub.3   OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-F    CH.sub.3   Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-F    CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 5-F    CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-F    CH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-F    CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 5-F    CH.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-F    CH.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-F    CH.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-F    CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 5-F    CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-F    CH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-F    CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 5-F    CH(CH.sub.3).sub.2                                                                        CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-F    CH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-F    CH(CH.sub.3).sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-F    CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 5-F    CH.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-F    CH(CH.sub.3)CH.sub.2 CH.sub.3                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-F    CH(CH.sub.3)CH.sub.2 CH.sub.3                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 5-F    CH.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-F    CH(CH.sub.3).sub.2                                                                        OCH.sub.3                                                                            OCH.sub. 3                                                                            N                                     H  A-1                                                                               --                                                                               O 5-F    CH(CH.sub.3).sub.2                                                                        Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-Cl   cyclopropyl                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 5-Cl   cyclopropyl                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-Cl   cyclopropyl                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-Cl   cyclopropyl                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 5-Cl   cyclopropyl                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-Cl   cyclopropyl                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-Cl   cyclopropyl                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR500##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR501##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR502##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR503##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR504##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR505##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR506##                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR507##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR508##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR509##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR510##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR511##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR512##                                                                               OCH.sub. 3                                                                           OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR513##                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR514##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR515##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR516##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR517##                                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR518##                                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR519##                                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-Cl                                                                                   ##STR520##                                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 CH.sub.2 F                                                             Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Cl                                                                     CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Cl                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Br                                                                     CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Br                                                                     CH.sub. 3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Br                                                                     OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2 CH.sub.2 Br                                                                     Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2CCH                                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2CCH                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2CCH                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2CCH                                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2CCH                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2CCH                                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-CH.sub.3                                                                            OCH.sub.2C CH                                                                             Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           NO.sub.2   CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           NO.sub.2   CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           NO.sub.2   OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           NO.sub.2   CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           NO.sub.2   CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           NO.sub.2   OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           NO.sub.2   Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         OCH.sub. 3                                                                           OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       OCH.sub. 3                                                                           OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.2 CH.sub.3                                                       Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH(CH.sub.3).sub.2                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 Cl                                                             CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                              CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                              OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 CH.sub.2 F                                                              Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub. 2 CF.sub.3                                                                 CO.sub.2 CH.sub.2 OCH.sub.3                                                               CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                               OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 5-OCH.sub.2 CF.sub.3                                                                  CO.sub.2 CH.sub.2 OCH.sub.3                                                               Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           CO.sub.2 CH.sub.2 CH.sub.3                                                                Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           SO.sub.2 N(CH.sub.3).sub.2                                                                Cl    OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O 6-OCH.sub.3                                                                           SO.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH.sub.2CHCH.sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH.sub.2CHCH.sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH.sub.2CHCH.sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH.sub.2CHCH.sub.2                                                                       Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH.sub.2 CH.sub.2 OCH.sub.3                                                              CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH.sub.2CCH                                                                              CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH(CH.sub.3).sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH(CH.sub.3).sub.2                                                                       CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH(CH.sub.3).sub.2                                                                       OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SCH(CH.sub.3).sub.2                                                                       Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SOCH.sub.3 CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SOCH.sub.3 CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SOCH.sub.3 OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SOCH.sub.3 CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SOCH.sub.3 CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SOCH.sub.3 OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SOCH.sub.3 Cl    OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             CH                                    CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.3                                                                              N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.3                                                                             N                                     CH.sub.3                                                                          A-1                                                                               --                                                                               O 6-F    SO.sub.2 CH.sub.3                                                                         Cl    OCH.sub.3                                                                             CH                                    __________________________________________________________________________     R  A  E W R.sub.1                                                                               R.sub.2    X.sub.1   Y.sub.1                                                                              m.p. (°C.)                  __________________________________________________________________________     H  A-2                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3  O                                        H  A-2                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2                                 H  A-2                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3 O                                        H  A-2                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3 CH.sub.2                                 H  A-2                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.2 CH.sub.3                                                                       O                                        H  A-2                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                              CH.sub.2                                 H  A-2                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                CH.sub.3  O                                        H  A-2                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                OCH.sub.3 O                                        H  A-2                                                                               --                                                                               O H      SO.sub.2 N(CH.sub.3).sub.2                                                                OCF.sub.2 H                                                                              CH.sub.2                                 __________________________________________________________________________     R  A  E W R.sub.1                                                                               R.sub.2    X.sub.1         m.p. (°C.)                  __________________________________________________________________________     H  A-3                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                           H  A-3                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                          H  A-3                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.2 CH.sub.3                                 H  A-3                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                        H  A-3                                                                               --                                                                               O H      Cl         CH.sub.3                                           H  A-3                                                                               --                                                                               O H      Cl         OCH.sub.3                                          H  A-3                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                         CH.sub.3                                           H  A-3                                                                               --                                                                               O H      SO.sub.2 CH.sub.3                                                                         OCH.sub.3                                          __________________________________________________________________________     R  A  E W R.sub.1                                                                               R.sub.2    X.sub.1   Y.sub.3                                                                              m.p. (°C.)                  __________________________________________________________________________     H  A-4                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3  H                                        H  A-4                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3 H                                        H  A-4                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.2 CH.sub.3                                                                       H                                        H  A-4                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                              H                                        H  A-4                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.3                                 H  A-4                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3 CH.sub.3                                 H  A-4                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                              CH.sub.3                                 __________________________________________________________________________     R  A  E W R.sub.1                                                                               R.sub.2    X.sub.2   Y.sub.2                                                                              m.p. (°C.)                  __________________________________________________________________________     H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3  OCH.sub.3                                H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3  OCH.sub.2 CH.sub. 3                      H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3  SCH.sub.3                                H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3  SCH.sub.2 CH.sub.3                       H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.3                                 H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.2 CH.sub.3                        H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                        OCH.sub.3                                H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                        SCH.sub.3                                H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                        OCH.sub.2 CH.sub.3                       H  A-5                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 CH.sub.3                                                                        OCH.sub.3                                __________________________________________________________________________     R  A  E W R.sub.1                                                                               R.sub.2    X.sub.3         m.p. (°C.)                  __________________________________________________________________________     H  A-6                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                           H  A-6                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                          H  A-6                                                                               --                                                                               O H      NO.sub.2   CH.sub.3                                           H  A-6                                                                               --                                                                               O H      NO.sub.2   OCH.sub.3                                          __________________________________________________________________________     R  A  E W R.sub.1                                                                               R.sub.2    X.sub.4   Y.sub.4                                                                              m.p. (°C.)                  __________________________________________________________________________     H  A-7                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3  CH.sub.3                                 H  A-7                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3  OCH.sub.3                                H  A-7                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3  OCH.sub.2 CH.sub.3                       H  A-7                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3  Cl                                       H  A-7                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3 CH.sub.3                                 H  A-7                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3 OCH.sub.3                                H  A-7                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.2 CH.sub.3                                                                       OCH.sub.3                                __________________________________________________________________________     R  A  E W R.sub.1                                                                               R.sub.2    X     Y      Z  m.p. (°C.)                  __________________________________________________________________________     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCH.sub.2 CH.sub.3                                                                    CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             OCF.sub.2 H                                                                           CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             SCF.sub.2 H                                                                           CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             SCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.2 OCH.sub.3                                                                    CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             NHCH.sub.3                                                                            N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             N(CH.sub.3).sub.2                                                                     N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CH.sub.2 F                                                                            CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CCH    CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             cyclopropyl                                                                           N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.3                                                                             CN     CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            CH.sub.2 CH.sub.3                                                                     CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCH.sub.2 CH.sub.3                                                                    CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            SCH.sub.3                                                                             N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            OCF.sub.2 H                                                                           CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            CH.sub.2 F                                                                            CH                                    H  A-1                                                                               --                                                                               O H      CO.sub. 2 CH.sub.3                                                                        OCH.sub.3                                                                            N(CH.sub.3).sub.2                                                                     N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            NHCH.sub.3                                                                            N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCH.sub.3                                                                            CN     N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                          CH.sub.3                                                                              CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                          OCH.sub.2 CH.sub.3                                                                    CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                          CH.sub.2 CH.sub.3                                                                     N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                          CH.sub.2 F                                                                            CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                          SCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                          N(CH.sub.3).sub.2                                                                     N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         OCF.sub.2 H                                                                          NHCH.sub.3                                                                            N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 OCH.sub.3                                                                   OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 OCH.sub.3                                                                   OCH.sub.2 CH.sub.3                                                                    CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 OCH.sub.3                                                                   CH.sub.3                                                                              N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 OCH.sub.3                                                                   CH.sub.2 F                                                                            CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 OCH.sub.3                                                                   CH.sub.2 Cl                                                                           CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CH.sub.2 OCH.sub.3                                                                   CH.sub.2 Br                                                                           CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         SCF.sub.2 H                                                                          OCH.sub.2 CH.sub.3                                                                    CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         SCF.sub.2 H                                                                          CH.sub.2 CH.sub.3                                                                     CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         SCF.sub.2 H                                                                          CH.sub.2 F                                                                            CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         SCF.sub.2 H                                                                          NHCH.sub.3                                                                            N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         N(CH.sub.3).sub.2                                                                    OCH.sub.2 CH.sub.3                                                                    N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         N(CH.sub.3).sub.2                                                                    CH.sub.2 CH.sub.3                                                                     N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         N(CH.sub.3).sub.2                                                                    CH.sub.2 F                                                                            N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         N(CH.sub.3).sub.2                                                                    CH.sub.2 OCH.sub.3                                                                    N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         N(CH.sub.3).sub.2                                                                    cyclopropyl                                                                           N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CCH   CH.sub.2 CH.sub.3                                                                     N                                     H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CCH   OCH.sub.3                                                                             CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CCH   N(CH.sub.3).sub.2                                                                     CH                                    H  A-1                                                                               --                                                                               O H      CO.sub.2 CH.sub.3                                                                         CCH   OCH.sub.2 CH.sub.3                                                                    N                                     __________________________________________________________________________

Formulations

Useful formulations of the compounds of Formula I can be prepared in conventional ways. They include dusts, granules, pellets, solutions, suspensions, emulsions, wettable powders, emulsifiable concentrates and the like. Many of these may be applied directly. Sprayable formulations can be extended in suitable media and used at spray volumes of from a few liters to several hundred liters per hectare. High strength compositions are primarily used as intermediates for further formulation. The formulations, broadly, contain about 0.1% to 99% by weight of active ingredient(s) and at least one of (a) about 0.1% to 20% surfactant(s) and (b) about 1% to 99.9% solid or liquid inert diluent(s). More specifically, they will contain these ingredients in the following approximate proportions:

    ______________________________________                                                     Active  Weight Percent*                                                        Ingredient                                                                             Diluent(s)                                                                               Surfactant(s)                                    ______________________________________                                         Wettable Powders                                                                             20-90      0-74     1-10                                         Oil Suspensions,                                                                              3-50     40-95     0-15                                         Emulsions, Solutions,                                                          (including Emulsifiable                                                        Concentrates)                                                                  Aqueous Suspension                                                                           10-50     40-84     1-20                                         Dusts          1-25     70-99     0-5                                          Granules and Pellets                                                                         0.1-95      5-99.9  0-15                                         High Strength 90-99      0-10     0-2                                          Compositions                                                                   ______________________________________                                          *Active ingredient plus at least one of a Surfactant or a Diluent equals       100 weight percent.                                                      

Lower or higher levels of active ingredient can, of course, be present depending on the intended use and the physical properties of the compound. Higher ratios of surfactant to active ingredient are sometimes desirable, and are achieved by incorporation into the formulation or by tank mixing.

Typical solid diluents are described in Watkins, et al., "Handbook of Insecticide Dust Diluents and Carriers", 2nd Ed., Dorland Books, Caldwell, New Jersey, but other solids, either mined or manufactured, may be used. The more absorptive diluents are preferred for wettable powders and the denser ones for dusts. Typical liquid diluents and solvents are described in Marsden, "Solvents Guide," 2nd Ed., New York, 1950. Solubility under 0.1% is preferred for suspension concentrates; solution concentrates are preferably stable against phase separation at 0° C. "McCutcheon's Detergents and Emulsifiers Annual", MC Publishing Corp., Ridgewood, New Jersey, as well as Sisely and Wood, "Encyclopedia of Surface Active Agents", Chemical Publishing Co., Inc., New York, 1964, list surfactants and recommended uses. All formulations can contain minor amounts of additives to reduce foaming, caking, corrosion, microbiological growth, etc.

The methods of making such compositions are well known. Solutions are prepared by simply mixing the ingredients. Fine solid compositions are made by blending and, usually grinding as in a hammer or fluid energy mill. Suspensions are prepared by wet milling (see, for example, Littler, U.S. Pat. No. 3,060,084). Granules and pellets may be made by spraying the active material upon preformed granular carriers or by agglomeration techniques. See J. E. Browning, "Agglomeration", Chemical Engineering, Dec. 4, 1967, pp. 147ff. and "Perry's Chemical Engineer's Handbook", 5th Ed., McGraw-Hill, New York, 1973, pp. 8-57ff.

For further information regarding the art of formulation, see for example: H. M. Loux, U.S. Pat. No. 3,235,361, Feb. 15, 1966, col. 6, line 16 through Col. 7, line 19 and Examples 10 through 41;

R. W. Luckenbaugh, U.S. Pat. No. 3,309,192, Mar. 14, 1967, Col. 5, line 43 through Col. 7, line 62 and Examples 8, 12, 15, 39, 41, 53, 58, 132, 138-140, 162-164, 166, 167 and 169-182;

H. Gysin and E. Knusli, U.S. Pat. No. 2,891,855, June 23, 1959, Col. 3, line 66 through Col. 5, line 17 and Examples 1-4;

G. C. Klingman, "Weed Control as a Science", John Wiley and Sons, Inc., New York, 1961, pp. 81-96; and

J. D. Fryer and S. A. Evans, "Weed Control Handbook", 5th Ed., Blackwell Scientific Publications, Oxford, 1968, pp. 101-103.

In the following Examples, all parts are by weight unless otherwise indicated.

EXAMPLE 9

    ______________________________________                                         Wettable Powder                                                                ______________________________________                                         N--[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino-                                                         80%                                                 carbonyl]-2-pyridinesulfonamide-1-oxide                                        sodium alkylnaphthalenesulfonate                                                                          2%                                                  sodium ligninsulfonate     2%                                                  synthetic amorphous silica 3%                                                  kaolinite                  13%                                                 ______________________________________                                    

The ingredients are blended, hammer-milled until all the solids are essentially under 50 microns, reblended, and packaged.

EXAMPLE 10

    ______________________________________                                         Wettable Powder                                                                ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-                                                         50%                                                methyl-2-pyridinesulfonamide-1-oxide                                           sodium alkylnaphthalenesulfonate                                                                            2%                                                low viscosity methyl cellulose                                                                              2%                                                diatomaceous earth          46%                                                ______________________________________                                    

The ingredients are blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in diameter. The product is reblended before packaging.

EXAMPLE 11

    ______________________________________                                         Granule                                                                        ______________________________________                                         Wettable powder of Example 10                                                                          5%                                                     attapulgite granules   95%                                                     (U.S.S. 20 to 40 mesh; 0.84-0.42 mm)                                           ______________________________________                                    

A slurry of wettable powder containing 25% solids is sprayed on the surface of attapulgite granules in a double-cone blender. The granules are dried and packaged.

EXAMPLE 12

    ______________________________________                                         Extruded Pellet                                                                ______________________________________                                         N--[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino-                                                         25%                                                 carbonyl]-2-pyridinesulfonamide-1-oxide                                        anhydrous sodium sulfate   10%                                                 crude calcium ligninsulfonate                                                                              5%                                                 sodium alkylnaphthalenesulfonate                                                                           1%                                                 calcium/magnesium bentonite                                                                               59%                                                 ______________________________________                                    

The ingredients are blended, hammer-milled and then moistened with about 12% water. The mixture is extruded as cylinders about 3 mm diameter which are cut to produce pellets about 3 mm long. These may be used directly after drying, or the dried pellets may be crushed to pass a U.S.S. No. 20 sieve (0.84 mm openings). The granules held on a U.S.S. No. 40 sieve (0.42 mm openings) may be packaged for use and the fines recycled.

EXAMPLE 13

    ______________________________________                                         Low Strength Granule                                                           ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-                                                          0.1%                                              methyl-2-pyridinesulfonamide-1-oxide                                           attapulgite granules        99.9%                                              (U.S.S. 20 to 40 mesh)                                                         ______________________________________                                    

The active ingredient is dissolved in a solvent and the solution is sprayed upon dedusted granules in a double-cone blender. After spraying of the solution has been completed, the material is warmed to evaporate the solvent. The material is allowed to cool and then packaged.

EXAMPLE 14

    ______________________________________                                         Granule                                                                        ______________________________________                                         N--[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino-                                                         80%                                                 carbonyl]-2-pyridinesulfonamide-1-oxide                                        wetting agent               1%                                                 crude ligninsulfonate salt (containing                                                                    10%                                                 5 to 20% of the natural sugars)                                                attapulgite clay            9%                                                 ______________________________________                                    

The ingredients are blended and milled to pass through a 100 mesh screen. This material is then added to a fluid bed granulator, the air flow is adjusted to gently fluidize the material, and a fine spray of water is sprayed onto the fluidized material. The fluidization and spraying are continued until granules of the desired size range are made. The spraying is stopped, but fluidization is continued, optionally with heat, until the water content is reduced to the desired level, generally less than 1%. The material is then discharged, screened to the desired size range, generally 14 to 100 mesh (1410 to 149 microns), and packaged for use.

EXAMPLE 15

    ______________________________________                                         Low Strength Granule                                                           ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-                                                         1%                                                 methyl-2-pyridinesulfonamide-1-oxide                                           N,N--dimethylformamide      9%                                                 attapulgite granules        90%                                                (U.S.S. 20 to 40 sieve)                                                        ______________________________________                                    

The active ingredient is dissolved in the solvent and the solution is sprayed upon dedusted granules in a double cone blender. After spraying of the solution has been completed, the blender is allowed to run for a short period and then the granules are packaged.

EXAMPLE 16

    ______________________________________                                         Aqueous Suspension                                                             ______________________________________                                         N--[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino-                                                          40%                                                carbonyl]-2-pyridinesulfonamide-1-oxide                                        polyacrylic acid thickener 0.3%                                                dodecylphenol polyethylene glycol ether                                                                   0.5%                                                disodium phosphate           1%                                                monosodium phosphate       0.5%                                                polyvinyl alcohol          1.0%                                                water                      56.7%                                               ______________________________________                                    

The ingredients are blended and ground together in a sand mill to produce particles essentially all under 5 microns in size.

EXAMPLE 17

    ______________________________________                                         Solution                                                                       ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-                                                          5%                                                methyl-2-pyridinesulfonamide-1-oxide, ammonium                                 salt                                                                           water                       95%                                                ______________________________________                                    

The salt is added directly to the water with stirring to produce the solution, which may then be packaged for use.

EXAMPLE 18

    ______________________________________                                         High Strength Concentrate                                                      ______________________________________                                         N--[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino-                                                          99%                                                carbonyl]-2-pyridinesulfonamide-1-oxide                                        silica aerogel             0.5%                                                synthetic amorphous silica 0.5%                                                ______________________________________                                    

The ingredients are blended and ground in a hammer-mill to produce a material essentially all passing a U.S.S. No. 50 screen (0.3 mm opening). The concentrate may be formulated further if necessary.

EXAMPLE 19

    ______________________________________                                         Wettable Powder                                                                ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-                                                          90%                                               methyl-2-pyridinesulfonamide-1-oxide                                           dioctyl sodium sulfosuccinate                                                                              0.1%                                               synthetic fine silica       9.9%                                               ______________________________________                                    

The ingredients are blended and ground in a hammer-mill to produce particles essentially all below 100 microns. The material is sifted through a U.S.S. No. 50 screen and then packaged.

EXAMPLE 20

    ______________________________________                                         Wettable Powder                                                                ______________________________________                                         N--[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino-                                                         40%                                                 carbonyl]-2-pyridinesulfonamide-1-oxide                                        sodium ligninsulfonate     20%                                                 montmorillonite clay       40%                                                 ______________________________________                                    

The ingredients are thoroughly blended, coarsely hammer-milled and then air-milled to produce particles essentially all below 10 microns in size. The material is reblended and then packaged.

EXAMPLE 21

    ______________________________________                                         Oil Suspension                                                                 ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-                                                         35%                                                methyl-2-pyridinesulfonamide-1-oxide                                           blend of polyalcohol carboxylic                                                                             6%                                                esters and oil soluble petroleum                                               sulfonates                                                                     xylene                      59%                                                ______________________________________                                    

The ingredients are combined and ground together in a sand mill to produce particles essentially all below 5 microns. The product can be used directly, extended with oils, or emulsified in water.

EXAMPLE 22

    ______________________________________                                         Dust                                                                           ______________________________________                                         N--[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino-                                                         10%                                                 carbonyl]-2-pyridinesulfonamide-1-oxide                                        attapulgite                10%                                                 Pyrophyllite               80%                                                 ______________________________________                                    

The active ingredient is blended with attapulgite and then passed through a hammer-mill to produce particles substantially all below 200 microns. The ground concentrate is then blended with powdered pyrophyllite until homogeneous.

EXAMPLE 23

    ______________________________________                                         Oil Suspension                                                                 ______________________________________                                         N--[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-                                                         25%                                                methyl-2-pyridinesulfonamide-1-oxide                                           polyoxyethylene sorbitol hexaoleate                                                                         5%                                                highly aliphatic hydrocarbon oil                                                                           70%                                                ______________________________________                                    

The ingredients are ground together in a sand mill until the solid particles have been reduced to under about 5 microns. The resulting thick suspension may be applied directly, but preferably after being extended with oils or emulsified in water.

EXAMPLE 24

    ______________________________________                                         Wettable Powder                                                                ______________________________________                                         N--[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino-                                                         20%                                                 carbonyl]-2-pyridinesulfonamide-1-oxide                                        sodium alkylnaphthalenesulfonate                                                                          4%                                                  sodium ligninsulfonate     4%                                                  low viscosity methyl cellulose                                                                            3%                                                  attapulgite                69%                                                 ______________________________________                                    

The ingredients are thoroughly blended. After grinding in a hammer-mill to produce particles essentially all below 100 microns, the material is reblended and sifted through a U.S.S. No. 50 sieve 0.3 mm opening) and packaged.

Utility

Test results indicate that the compounds of the present invention are highly active preemergent or postemergent herbicides or plant growth regulants. Many of them have utility for broad-spectrum pre- and/or post-emergence weed control in areas where complete control of all vegetation is desired, such as around fuel storage tanks, industrial storage areas, parking lots, drive-in theaters, around billboards, highway and railroad structures. Some of the compounds have utility for selective weed control in crops such as wheat, barley and corn. Alternatively, the subject compounds are useful to modify plant growth.

The rates of application for the compounds of the invention are determined by a number of factors, including their use as plant growth modifiers or as herbicides, the crop species involved, the types of weeds to be controlled, weather and climate, formulations selected, mode of application, amount of foliage present, etc. In general terms, the subject compounds should be applied at levels of around 0.01 to 10 kg/ha, the lower rates being suggested for use on lighter soils and/or those having a low organic matter content, for plant growth modification or for situations where only short-term persistence is required.

The compounds of the invention may be used in combination with any other commercial herbicide, examples of which are those of the triazine, triazole, uracil, urea, amide, diphenylether, carbamate and bipyridylium, imidazolinone types.

The herbicidal properties of the subject compounds were discovered in a number of greenhouse tests. The test procedures and results follow.

    ______________________________________                                         Compounds                                                                      Compound                                                                               R.sub.1 R.sub.2     X      Y      Z                                    ______________________________________                                          ##STR521##                                                                    1               H           CH.sub.3                                                                              CH.sub.3                                                                              CH                                   2               H           CH.sub.3                                                                              OCH.sub.3                                                                             CH                                   3               H           OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                   4               H           CH.sub.3                                                                              CH.sub.3                                                                              N                                    5               H           CH.sub.3                                                                              OCH.sub.3                                                                             N                                    6               H           OCH.sub.3                                                                             OCH.sub.3                                                                             N                                    7               CH.sub.3    CH.sub.3                                                                              CH.sub.3                                                                              CH                                   8               CH.sub.3    CH.sub.3                                                                              OCH.sub.3                                                                             CH                                   9               CH.sub.3    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                   10              CH.sub.3    CH.sub.3                                                                              OCH.sub.3                                                                             N                                    11              CH.sub.3    OCH.sub.3                                                                             OCH.sub.3                                                                             N                                    12              CH.sub.3    Cl     OCH.sub.3                                                                             CH                                   13              cyclopropyl CH.sub.3                                                                              CH.sub.3                                                                              CH                                   14              cyclopropyl CH.sub.3                                                                              OCH.sub.3                                                                             CH                                   15              cyclopropyl OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                   16              cyclopropyl OCH.sub.3                                                                             OCH.sub.3                                                                             N                                    17              CH(CH.sub.3).sub.2                                                                         CH.sub.3                                                                              CH.sub.3                                                                              CH                                   18              CH(CH.sub.3).sub.2                                                                         OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                    ##STR522##                                                                    19      SCH.sub.3                                                                              H           CH.sub.3                                                                              CH.sub.3                                                                              CH                                   20      SCH.sub.3                                                                              H           CH.sub.3                                                                              OCH.sub.3                                                                             CH                                   21      SCH.sub.3                                                                              H           OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                   22      SCH.sub.3                                                                              H           CH.sub.3                                                                              OCH.sub.3                                                                             N                                    23      SCH.sub.3                                                                              H           OCH.sub.3                                                                             OCH.sub.3                                                                             N                                    24      SCH.sub.3                                                                              H           Cl     OCH.sub.3                                                                             CH                                   25      H       OC.sub.2 H.sub.5                                                                           OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                   26      H       OC.sub.2 H.sub.5                                                                           CH.sub.3                                                                              OCH.sub.3                                                                             N                                    27      H       OC.sub.2 H.sub.5                                                                           Cl     OCH.sub. 3                                                                            CH                                   28      SCH.sub.3                                                                              SCH.sub.3   CH.sub.3                                                                              OCH.sub.3                                                                             CH                                    ##STR523##                                                                    29              CH.sub.3    OCH.sub.3                                                                             OCH.sub.3                                                                             CH                                   30              CH.sub.3    CH.sub.3                                                                              OCH.sub.3                                                                             CH                                   31              CH.sub.3    CH.sub.3                                                                              OCH.sub.3                                                                             N                                    ______________________________________                                    

Test A

Seeds of crabgrass (Digitaria spp.), barnyardgrass (Echinochloa crusgalli), giant foxtail (Setaria faberi), wild oats (Avena fatua), cheatgrass (Bromus secalinus), velvetleaf (Abutilon theophrasti), morningglory (Ipomoea spp.), cocklebur (Xanthium pensylvanicum), sorghum, corn, soybean, sugarbeet, cotton, rice, wheat, barley and purple nutsedge (Cyperus rotundus) tubers were planted and treated preemergence with the test chemicals dissolved in a non-phytotoxic solvent. At the same time, these crop and weed species were treated with a soil-foliage application. At the time of treatment, the plants ranged in height from 2 to 18 cm. Treated plants and controls were maintained in a greenhouse for sixteen days, after which all species were compared to controls and visually rated for response to treatment. The ratings, summarized in Table A, are based on a numerical scale extending from 0=no injury, to 10=complete kill. The accompanying descriptive symbols gave the following meanings:

C=chlorosis/necrosis;

B=burn;

D=defoliation;

E=emergence inhibition;

G=growth retardation;

H=formative effect;

U=unusual pigmentation;

X=axillary stimulation;

S=albinism; and

6Y=abscised buds or flowers.

A dash (-) response means no test. Response ratings are contained in Table A.

    TABLE A       CMPD 1 CMPD 2 CMPD 3 CMPD 4 CMPD 5 CMPD 6 CMPD 7 CMPD 8 CMPD 9 CMPD 10      CMPD 11 RATE = KG/HA 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01      0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01        POSTEMERGENCE COTTON 0 -- 4C,9G -- 4C,9G -- 0 -- 0 -- 0 -- 3C,7H 2C 9H 2      C,8G 3C,9G 2C,9H 9H 1C 4C,9H 3C,6G MORNING GLORY 2H -- 5C,9G -- 10C -- 0      -- 0 -- 1H -- 4C,8H 2C,2H 4C,9G 2C,7G 10C 9C 5C,9G 3C,8H 5C,9G 3C,8H      COCKLEBUR 0 -- 4C,9G -- 9C -- 0 -- 3C,5H -- 0 -- 4C,8G 2C,4G 8G 2C,7G      10C 7G 4C,9H 6G 6H 3G NUTSEDGE 0 -- 2C,9G -- 5C,9G -- 0 -- 0 -- 0 --      4C,8G 0 9G 8G 4C,9G 9G 2G 0 0 0 CRABGRASS 0 -- 2G -- 2C,8G -- 0 -- 0 --      2G -- 7G 0 8G 5G 4C,9G 3C,7G 2C,8G 3G 0 0 BARNYARD GRASS 0 -- 4C,9H --      9C -- 0 -- 3C,8H -- 2C,8H -- 3C,9H 3C,6H 5C,9G 4C,9H 10C 4C,9H 9C 3C,7H      5C,9G 3C,7H WILD OATS -- -- -- -- -- -- -- -- -- -- -- -- 2G 0 6G 3C,6G      2C,8G 5G 3G 0 1C 0 WHEAT 0 -- 2C,3G -- 4C,9G -- 0 -- 0 -- 2G -- 7G 4G 7G      5G 4C,9G 4C,9G 9G 0 7G -- CORN 0 -- 9C -- 4C,9G -- 0 -- 3C,9H -- 4H --      3C,7G 1C,3G 4C,9G 2C,9G 9C 3C,9G 9C 4C,9G 5C,9G 4C,9G SOYBEAN 0 -- 5C,9G      -- 5C,9G -- 0 -- 2C,7G -- 2C,4G -- 3C,9H 3C,3H 5C,9G 3C,8G 5C,9G 3C,9G      5C,9G 2C,4G 5C,9G 2C,2H RICE 6G -- 9C -- 9C -- 0 -- 5C,9G -- 5C,9G --      5C,9G 3C,8G 5C,9G 3C,9G 5C,9G 5C,9G 6C,9G 4C,9G 5C,9G 4C,9G SORGHUM 2G      -- 9G -- 4C,9G -- 0 -- 3C,9H -- 3C,8H -- 4C,9G 2C,5G 3C,9G 3C,8G 3C,9G      5C,9G 5C,9G 4C,9H 4C,9G 3C,9G CHEATGRASS 0 -- 4C,8G -- 5C,9G -- 0 --      2C,4G -- 2C,4G -- 9G 5G 9G 7G 9C 4C,9G 3C,7G 2C,5G 8G 0 SUGAR BEETS 1H      -- 9C -- 9C -- 2H -- 2H -- 4H -- 4C,9G 3C,7H 10C 5C,9G 9C 9C 5C,9H 3C,5H      9C 4C,9G VELVETLEAF 0 -- 5C,9G -- 9C -- 0 -- 1C -- 1C -- 4C,9H 3C,3H 9C      4C,9G 9C 9C 4C,9H 3C,7H 4C,9H 3C,6H GIANT FOXTAIL -- -- -- -- -- -- --      -- -- -- -- -- 3C,7G 2G 4C,9G 3C,7H 5C,9G 4C,9G 3C,7G 2C,3G 0 0 BARLEY      -- -- -- -- -- -- -- -- -- -- -- -- -- 5G 8G -- 9C 3C,8G 9C 2G 3G --      DOWNY BROME PREEMERGENCE COTTON -- -- -- -- -- -- -- -- -- -- -- -- 0 0      2G 0 7G 3G  2G 0 0 0 MORNING GLORY -- -- -- -- -- -- -- -- -- -- -- -- 0      0 0 0 7G 3C,3H 1H 0 0 0 COCKLEBUR -- -- -- -- -- -- -- -- -- -- -- -- 0      0 1C 0 3C,3G 2C,2H 3G 0 2G 0 NUTSEDGE -- -- -- -- -- -- -- -- -- -- --      -- -- 0 0 0 2C,3G 3G0 0 0 0 CRABGRASS -- -- -- -- -- -- -- -- -- -- --      -- 0 0 3G 0 4G 2G 0 0 0 0 BARNYARD GRASS -- -- -- -- -- -- -- -- -- --      -- -- 0 0 2G 0 3C,8H 2G 2C,3G 0 0 0 WILD OATS -- -- -- -- -- -- -- -- --      -- -- -- 0 0 0 0 3G 0 0 0 0 0 WHEAT -- -- -- -- -- -- -- -- -- -- -- --      0 0 0 0 0 0 0 0 0 0 CORN -- -- -- -- -- -- -- -- -- -- -- -- 0 0 0 0      3C,5G 4G 0 0 0 0 SOYBEAN -- -- -- -- -- -- -- -- -- -- -- -- 2G 0 2C 0      2C,6G 2H 0 0 1C 0 RICE -- -- -- -- -- -- -- -- -- -- -- -- 2G 0 0 0      3C,8G 3G 0 0 0 0 SORGHUM -- -- -- -- -- -- -- -- -- -- -- -- 3C 0 3C 0      3C,8G 3C,5G 3G 0 3C,3G 0 CHEATGRASS -- -- -- -- -- -- -- -- -- -- -- --      0 0 0 0 8G 5G 0 0 0 0 SUGAR BEETS -- -- -- -- -- -- -- -- -- -- -- -- 5H      0 1H 0 2C,6H 2H 5G 3G 3H 0 VELVETLEAF -- -- -- -- -- -- -- -- -- -- --      -- 2C 0 2C 0 7G 7H 2C 0 2C 0 GIANT FOXTAIL -- -- -- -- -- -- -- -- -- --      -- -- 0 0 6G 0 3C,6G 0 0 0 0 0 BARLEY -- -- -- -- -- -- -- -- -- -- --      -- 0 0 0 0 2G 0 0 0 0 0 DOWNY BROME        CMPD 12 CMPD 13 CMPD 14 CMPD 15 CMPD 16 CMPD 17 CMPD 18 CMPD 19 CMPD      20  CMPD 21 RATE = KG/HA 0.05 0.01 0.01 0.05 0.01 0.05 0.01 0.05 0.01      0.05 0.01 0.05 0.01 0.05 0.01 0.05  0.01 0.05 0.01 0.05        POSTEMERGENCE COTTON 3C,8G 3G 2C,4G 3C,7G 6G 9G 2C,6G 3C,9H 2C,5G      4C,9G 2C,4G 2C,7H 3C,9G 5C,9G 0 0  6G  2G 2C,2G 3C,6G MORNING GLORY      4C,8G 2C,6G 1H 2C,7G 3C,6G 4C,9G 3C,8G 9C 4C,9G 9C 3C,7G 2C,8G 1C 10C 0      0 2C,3H 2C,4G 1C 3C,7G COCKLEBUR 7G 1C 2C,5G 9C 10C 4C,8H 10C 10C 9C 10C      2C,7G 3C,9H 5C,9H 10C 0 0 3C,5G 4C,9G 3C,8H 3C,9H NUTSEDGE 4C,8G -- 6G      3C,5G 7G 3C,8G 10C 9C 7G 8G 0 7G 9G 3C,9G 0 0 0 2C,8G 5G 5C,9G CRABGRASS      0 0 6G 6G 4G 6G 5G 9C 3C,7G 10C 0 2G 5G 8G 0 0 0 5G 0 4C,8G BARNYARD      GRASS 3C,9H 5H 10C 5C,9H 9H 9C 10C 9C 5C,9H 10C 4C,8H 5C,9H 4C,9H 9C 0 0      0 0 0 3C,5G WILD OATS 0 0 3C,7G 4C,9G 3C,7G 2C,9G 2C,9G 5C,9G 5C,9G 9C      9G 4C,9G 3C,9G 5C,9G 0 0 0 0 0 0 WHEAT 0 0 8G 9G 8G 3C,9G 2C,9G 5C,9G      5C,9G 9C 9G 3C,9G 9G 5C,9G 0 0 0 8G 0 3G CORN 3C,7G 2G 3C,9G 3C,9G 2C,9G      9C 3C,9G 10C 9C 9C 3C,8H 8G 3C,9G 6U,9G 0 0 0 4C,9H 3C,7G 3C,9G SOYBEAN      3H 0 4C,8G 5C,9G 4C,9G 9C 5C,9G 9C 5C,9G 9C 3C,8G 5C,9G 5C,9G 5C,9G 0 0      2H 3C,8G 2C,4H 4C,9H RICE 5C,9G 3C,6G 5C,9G 9C 9G 9C 9C 9C 9C 9C 8G      5C,9G 4C,9G 5C,9G 0 0 0 3C,5G 2G 5C,9G SORGHUM 4C,9H 3C,7H 2C,9G 4C,9G      3C,9G 3C,9G 9C 9C 3C,9G 9C 3C,8H 3C,9G 3C,9G 6C,9G 0 0 3G 4C,9H 7G 3C,9H      CHEATGRASS 2C,5G 0 8G 9C 3C,7G 5C,9G 9C 9C 5C,9G 9C 9G 9G 4C,9G 9C 0 0 0      2C,8G 3G 2C,9G SUGAR BEETS 9C 4C,8G 5C,9G 5C,9G 9C 5C,9G 5C,9G 10C 9C      10C 3C,8H 3C,8H 3C,8G 10C 0 0 3C,6H 10C 5C,9G 9C VELVETLEAF 8H 2C,5G      3C,9G 10C 10C 4C,9G 10C 10C 5C,9H 5C,9H 3C,8H 5C,9G 5C,9H 4C,9G 0 0      3C,5G 4C,9G 3C,7H 5C,9G GIANT FOXTAIL 2C,5G 3G 3C,5G 9G 3C,6G 2C,8G      4C,8G 9C 3C,7G 9C 0 0 3C,9G 9C 0 0 0 3C,6G 0 3C,5G BARLEY 0 0 3C,7G      2C,9G 3C,7G 3C,8G 2C,9G 5C,9G 9G 9C 7G 9G 2C,8G 3C,8G 0 0 0 0 0 0 DOWNY      BROME PREEMERGENCE COTTON 5G 0 0 3G 0 3G  3G 2G 6G 0 3G 4G 9G 0 0 0 0 0      0 MORNING GLORY 3G 0 0 0 0 2G 0 2G 2C,2G 8G 0 0 0 9G 0 0 0 0 0 0      COCKLEBUR 3G -- 0 0 0 0 3G 2C,5H 1C 2C,2H 0 0 8G 9H 0 0 0 1C 0 3C      NUTSEDGE 0 0 0 0 0 0 9G 10E 0 0 0 0 5G 10E 0 0 0 0 0 0 CRABGRASS 0 0 0 0      0 0 2G 3C,6G 0 3C,5G 0 0 7G 8G 0 0 0 0 0 0 BARNYARD GRASS 3G 0 0 2G 0 2G      3G 9H 0 3C,8G 0 0 3C,8H 9H 0 0 0 0 0 0 WILD OATS 0 0 0 3G 0 2G 7G 3C,8G      0 3C,6G 0 0 3G 8G 0 0 0 0 0 0 WHEAT 0 0 0 5G 0 3G 8G 2C,8H 3G 8G 0 0 8G      9G 0 0 0 0 0 0 CORN 3G 0 0 2C,4G 0 3C,4G 3C,6G 3C,9G 3C,5G 3C,7G 0 2C,3G      3C,8H 9G 0 0 0 0 0 2C,3G SOYBEAN 2G 0 0 3C,4H 0 1C 3C,7G 3C,8G 2C,4G      4C,8G 0 1C 1C,3G 4C,8H 0 0 0 0 0 2C RICE 6G 0 0 3C,7G 0 0 9H 10H 3G      4C,9G 0 2C 2C,8G 10H 0 0 0 0 0 0 SORGHUM 3C,6G 0 0 3C,5G 0 2C,3G 3C,9H      9H 3C,5G 3C,9G 0 1C,2G 9G 5C,9H 0 0 0 0 2C 2C,4G CHEATGRASS 0 0 0 6G 0      3G 7G 9H 0 3C,8G 0 0 7G 4C,9H 0 0 0 0 0 0 SUGAR BEETS 0 0 0 2H 0 4G 8G      9G 5G 3C,6G 0 1C,3G 2G 9G 0 0 0 2G 2H 3H VELVETLEAF 2G 0 0 7H 4G 3H 8G      4C,9G 0 2C,5H 0 2C,3H 8G 4C,9G 0 0 0 0 0 0 GIANT FOXTAIL 0 0 0 0 0 0 7G      9H 0 2C,2G 0 0 2C,8G 3C,9G 0 0 0 0 0 0 BARLEY 0 0 0 2G 0 0 6G 3C,8G      2C,2G 8G 0 3G 9G 9G 0 0 0 0 0 0 DOWNY BROME        CMPD 22 CMPD 23 CMPD 24 CMPD 25 CMPD 26 CMPD 27 CMPD 28 CMPD 29 CMPD      30  CMPD 31 RATE = KG/HA 0.01 0.05 0.01 0.05 0.01 0.05 0.01 0.05 0.01      0.05 0.01 0.05 0.01 0.05 0.01 0.05  0.01 0.05 0.01 0.05        POSTEMERGENCE COTTON 0 0 0 3C,4G 0 0 2G 5C,9G 0 3C,5G 4G 3C,6G 0 0 0 0 0       0 0 0 MORNING GLORY 0 3C,6G 0 1H 0 0 9C 10C 3C,6G 4C,8G 3C,5G 5C,9G      2C,5G 3C,8H 0 0 0 0 2H 3H COCKLEBUR 3H 3C,8G 2H 3C,8H 0 3G 3C,9G 10C 7G      4C,8H 4G 4C,9G 3C,8H 5C,9G 0 0 0 0 0 0 NUTSEDGE 0 0 0 0 0 0 10C 10C 0 0      4G 5C,9G 3G  0 0 0 0 0 0 CRABGRASS 0 0 0 2G 0 0  3C,7G 0 4C,8G 3G 3C,6G      0 3G 0 0 0 0 0 0 BARNYARD GRASS 0 3G 0 2G 0 0 5C,9G 10C 3C,9H 10C 3C,7H      5C,9G 0 3C,7H 0 0 0 0 0 0 WILD OATS 0 0 0 0 0 0 3C,9G 5C,9G 3C,5G 5C,9G      0 5 0 3G 0 0 0 0 0 0 WHEAT 0 0 0 0 0 0 8G 5C,9G 3C,6G 4C,9G 0 5G 0 3G 0      0 0 0 0 0 CORN 0 4G 0 0 0 3G 9C 10C 9C 9C 9G 9C 0 3C,9G 0 0 0 0 0 0      SOYBEAN 0 3C,3H 0 3C,4H 0 0 9C 5C,9G 3C,8G 5C,9G 5G 4C,9G 1H 3C,7H 0 0 0      0 0 0 RICE 0 3C,4G 0 4G 0 0 4C,9G 5C,9G 9C 5C,9G 4C,9G 5C,9G 0 8G 0 0 0      0 0 0 SORGHUM 0 3C,7G 0 2G 0 4G 9C 10C 5C,9G 9C 4C,9G 5C,9G 2G 3C,9G 0      2G 0 0 0 0 CHEATGRASS 0 0 0 0 0 0       3G 2G SUGAR BEETS 3C,4G 9C 0      5C,9G 0 3C,8H 9C 5C,9G 4C,9H 4C,8H 3C,8G 9C 3C,5G 9C 0 9C 0 0 0 0      VELVETLEAF 0 3C,6G 0 3C,8G 0 0 5C,9G 9C 0 3C,6G 3C,7G 9C 2G 4C,9G 2G 10C      0 0 0 0 GIANT FOXTAIL 0 0 0 3G 0 0 9C 9C 0 0 0 0 0 2G 0 0 0 0 0 0 BARLEY      0 0 0 0 0 0 4C,9G 9C 7G 4C,9G 3G 5G 0 3G 0 0 0 0 0 0 DOWNY BROME      4C,9G 3C,9G 7G 3C,5G 0 7G   0 5G 0 0 0 0 PREEMERGENCE COTTON 0 0 0 0 0 0 0       7G 0 0 5G 5G 0 0 0 0 0 0 0 0 MORNING GLORY 0 0 0 0 0 0 7G 9G 0 0 3G 8G      0 0 0 0 0 0 0 0 COCKLEBUR 0 0 0 0 0 0 6G 3C,8H 0 0 1H 3C,7G 0 0 0 0 0 0      0 0 NUTSEDGE 0 0 0 0 0 0 10E 10E 0 0 0 9G 0 0 0 0 0 0 0 0 CRABGRASS 0 0      0 0 0 0 3C,6G 3C,9G 0 2G 2G 3C,7G 0 0 0 0 0 0 0 0 BARNYARD GRASS 0 0 0 0      0 0 3C,5G 9H 0 3C,7H 2C 7G 0 0 0 0 0 0 0 0 WILD OATS 0 0 0 0 0 0 3C,3G      3C,8H 0 0 0 0 0 0 0 0 0 0 0 0 WHEAT 0 0 0 0 0 0 2C,6G 9H 0 0 0 0 0 0 0 0      0 0 0 0 CORN 0 0 0 0 0 0 3C,7H 3C,9G 0 0 2G 3C,8G 0 0 0 0 0 0 0 0      SOYBEAN 0 0 0 0 0 0 3C,8G 3C,8H 0 0 2G 3C,6H 0 0 0 0 0 0 0 0 RICE 0 0 0      0 0 0 8H 9H 0 0 3G 9H 0 0 0 0 0 0 0 0 SORGHUM 0 0 0 0 0 0 3C,8H 10H 0      3C,8H 5G 3C,9G 0 0 0 0 0 0 0 0 CHEATGRASS 0 0 0 0 0 0       0 0 SUGAR      BEETS 0 0 0 0 0 0 8G 7G 0 2H 4G 5G 0 0 0 0 0 0 0 0 VELVETLEAF 0 0 0 0 0      0 6H 3C,9G 0 0 0 2C,4H 0 0 0 0 0 0 0 0 GIANT FOXTAIL 0 0 0 0 0 0 3C,5G      3C,9H 0 0 0 2G 0 0 0 0 0 0 0 0 BARLEY 0 0 0 0 0 0 3C,6G 2C,8G 0 0 0 2G 0      0 0 0 0 0 0 0 DOWNY BROME       8G 3C,8H 0 0 2G 5G   0 0 0 0 0 0

Test B

Postemergence

Three round pans (25 cm diameter by 12.5 cm deep) were filled with Sassafras sandy loam soil. One pan was planted with nutsedge (Cyperus rotundus) tubers, crabgrass (Digitaria sanguinalis), sicklepod (Cassia obtusifolia), jimsonweed (Datura stramonium), velvetleaf (Abutilon theophrasti), lambsquarters (Chenopodium album), rice (Oryza sativa) and teaweed (Sida spinosa). The second pot was planted with green foxtail (Setaria viridis), cocklebur (Xanthium pensylvanicum), morningglory (Ipomoea hederacea), cotton (Gossypium hirsutum), johnsongrass (Sorghum halepense), barnyardgrass (Echinochloa crusgalli), corn (Zea mays), soybean (Glycine max) and giant foxtail (Setaria faberia). The third pot was planted with wheat (Triticum aestivum), barley (Hordeum vulgare), wild buckwheat (Polgonum convolvulus L.), cheatgrass (Bromus secalinus L.), sugarbeet (Beta vulgaris), wild oat (Avena fatua), viola (Viola arvensis), blackgrass (Alpercurus myosuroides), and rape (Brassica napus). The plants were grown for approximately fourteen days, then sprayed postemergence with the chemicals dissolved in a non-phytotoxic solvent.

Preemergence

Three round pans (25 cm diameter by 12.5 cm deep) were filled with Sassafras sandy loam soil. One pan was planted with nutsedge tubers, crabgrass, sicklepod, jimsonweed, velvetleaf, lambsquarters, rice and teaweed. The second pot was planted with green foxtail, cocklebur, morningglory, cotton, johnsongrass, barnyardgrass, corn, soybean and giant foxtail. The third pot was planted with wheat, barley, wild buckwheat, cheatgrass, sugarbeet, wild oat, viola, blackgrass and rape. The three pans were sprayed preemergence with the chemicals dissolved in a non-phytotoxic solvent.

Treated plants and controls were maintained in the greenhouse for 24 days, then all rated plants were compared to controls and visually rated for plant response.

Response ratings are based on a scale of 0 to 100 where 0=no effect and 100=complete control. A dash (-) response means no test.

Response ratings are contained in Table B.

    TABLE B       CMPD 2 CMPD 3 CMPD 9 CMPD 10 CMPD 15 CMPD 16 CMPD 18 RATE = G/HA 1. 4.      16. 62. 250. 0250 0062 0016 0004 0016 0016 0004 0004 0016 0062  0004      0016 0062   0001 0004 0016 0062        PREEMERGENCE GIANT FOXTAIL      -- -- 50 90 100 90 80 0 0 0 0 0  50 80        0 30      VELVETLEAF      -- -- 30 90 90 90 90 80 0 40 0 0 60 90 100      30 50 70  20 80 100 100 SUGAR BEETS      -- -- 0 70 90 90 -- 50 30 70 0      0  90 100   30 70  30 70 100 100 CRABGRASS      -- -- 20 50 90        50      70 80  0 30 60  0 20 70 80 TEAWEED      -- -- 0 40 90 90 0 0 0 0 0 0 50      70 80  0 30 60  50 60 80 100 JIMSONWEED      -- -- 0 40 80 90 0 0 0 0 0      0 30 50 90  0 30 50  0 20 40 80 RICE      -- -- 60 90 100 100 70 50 30      40 0 0 90 100 100  30 50 80  40 80 80 100 COCKLEBUR      -- -- 0 0 20 80      40 40 0 30 20 0 30 60 70  0 30 50  0 30 50 80 COTTON      -- -- 0 20 60      90 70 20 0 0 0 0 0 20 30  0 0 30  20 30 50 100 SOYBEAN      -- -- 0 10      80 80 50 30 0 20 0 0  30 50   0 0  0 20 40 70 BARNYARD      -- -- 20 50      90 90 40 20 0 0 0 0 0 30 70  0 30 60  30 40 100 100GRASS WILD OATS      -- -- 0 0 40 50 40 0 0 0 0 0  30 50   0 30  20 40 70 90 MORNINGGLORY       -- -- 0 0 50 80 50 20 20 20 20 0 0 30 50  0 0 30  0 0 20 50 WHEAT      -- -- 0 0 0 30 0 0 0 0 0 0  30 60   0 30  20 40 80 90 CASSIA      -- --      0 80 90        80 90 100   50 100   30 70 100 JOHNSONGRASS      -- -- 20      80 90 80 70 30 0 0 0 0 60 90 100  50 70 80  30 50 70 80 NUTSEDGE      --      -- 20 70 90 90 60 0 0 0 0 0 30 50 100  0 0 30  0 0 30 90 CORN      -- --      0 10 80 50 20 0 0 0 0 0  0 60   0 30  0 20 100 100 WILD      -- -- -- --      --         50 70   30 50  20 80 90 100 BUCKWHEAT BLACK GRASS      -- --      30 80 90 80 50 0 0 0 0 0  80 90   50 70  40 60 80 80 RAPESEED      -- --      0 0 80 90 70 30 0 0 0 0  50 70   30 50  30 70 100 100 BARLEY      -- --      -- -- -- 30 0 0 0 0 0 0  30 60   0 30  20 40 70 80 GREEN FOXTAIL      --      -- -- -- -- 90 70 30 0 0 0 0 30 70 100  0 30 50  30 50 100 100 CHEAT      GRASS      -- -- -- -- -- 80 70 0 0 20 0 0  70 90   50 70  70 80 90 90      BUCKWHEAT     -- -- -- -- -- VIOLA      -- -- -- -- -- 90 80 0 0 20 0 0      LAMBSQUARTER      -- -- -- -- -- 100 70 60 0 70 0 0 100 100 100  50 80      90  20 60 70 100 CHICK WEED                   70 80      50 70 90      90       RATE = G/HA 1. 4. 16. 62. 250. 1. 4. 16. 62. 250. 0250 0062      0016 0004 0062 0016 0004 0001 0004 0016 0062 0001 0004 0016 00620001      00040016 0062        POSTEMERGENCE GIANT FOXTAIL -- 0 0 0.0 50 0 0 0 40 -- 100 80 70 50 90      30 20 20 40 60 90  0 0 50 90 20 30 80 100 VELVETLEAF -- 20 70 100.30 90      0 30 90 100 -- 100 100 100 80 90 70 40 60 80 90 100 30 80 90 100 30 60      100 100 SUGAR BEETS -- 50 100 100.0 50 50 90 100 100 -- 100 100 100 60      80 80 70 0 70 100 100 0 50 100 100 20 40 70 80 CRABGRASS -- 0 0 30.20 40      0 0 0 30 --        0 20 40 60 20 40 80 100 20 40 70 80 TEAWEED -- 0 40      80.20 50 0 0 40 70 -- 90 80 50 50 70 60 40 20 40 60 90 0 40 80 90 20 40      80 100 JIMSONWEED -- 20 70 80.0 60 0 0 30 70 -- 100 90 70 60 100 70 50      30 40 60 100 0 30 50 70 20 40 70 90 RICE -- 20 80 100.50 90 20 50 100      100 -- 100 100 100 50 100 90 90 60 90 90 100 80 90 100 100 50 80 100 100      COCKLEBUR -- 0 0 0.0 0 0 0 20 90 -- 100 50 30 20 70 30 0 30 50 100 100      30 80 100 100 0 50 100 100 COTTON -- 30 40 100.0 0 0 20 60 100 -- 80 70      70 20 50 20 0 0 0 20 30 0 30 40 90  20 50 SOYBEAN -- 30 90 100.0 40 0 50      100 100 -- 100 90 80 50 90 50 50 40 90 100 100 50 80 100 100 40 100 100      100 BARNYARD -- 0 0 30.0 0 0 0 30 60 -- 100 90 80 60 100 70 30 70 90 100      100 40 90 100 100 60 90 100 100 GRASS WILD OATS -- 0 0 0.0 0 0 0 0 30 --      90 70 40 30 40 30 0 40 90 90 100 30 90 100 100  70 90 90 MORNINGGLORY --      0 50 100.0 50 0 20 60 80 -- 100 100 90 30 80 30 30 0 40 90 90 0 60 90      100 0 20 80 100 WHEAT -- 0 0 0.0 0 0 0 0 0 -- 60 40 10 0 10 0 0 40 50 70      100 40 50 90 100 50 80 100 100 CASSIA -- 20 80 100.50 80 0 30 80 100 --            50 90 100 100 30 85 90 100 40 90 100 100 JOHNSONGRASS -- 0 0 40.40      80 0 30 80 100 -- 100 80 50 30 60 50 20 50 85 100 100 30 60 90 100 30 90      100 100 NUTSEDGE -- 0 0 20.20 50 0 0 40 100 -- 100 80 60 30 0 0 0 40 90      100 100 0 0 20 40 20 100 100 100 CORN -- 50 100 100.0 30 30 90 100 100      -- 100 90 80 60 80 60 20 80 90 100 100 90 100 100 100 80 90 100 100 WILD      -- -- -- -- -- -- -- -- -- --        30 50 90 100 30 80 100 100 30 40      100 100 BUCKWHEAT BLACK GRASS -- 0 0 0.50 80 0 0 0 40 -- 80 70 40 40 30      0 0 40 90 100 100 40 70 100 100  60 100 100 RAPESEED -- 50 90 100.0 80      50 70 100 100 -- 100 100 100 100 100 100 70 60 100 100 100 60 100 100      100  100 100 100 BARLEY -- -- -- -- -- -- -- -- -- -- 70 60 10 0 10 10 0      50 60 80 100 40 90 100 100 40 80 90 100 GREEN FOXTAIL -- -- -- -- -- --      -- -- -- -- 100 100 80 70 90 80 40 40 60 80 90 0 40 80 90 30 50 100 100      CHEAT GRASS -- -- -- -- -- -- -- -- -- -- 90 80 70 60 60 50 40 30 50 90      100 0 40 90 100 50 70 100 100 BUCKWHEAT -- -- -- -- -- -- -- -- -- --      VIOLA -- -- -- -- -- -- -- -- -- -- -- -- -- 0 -- -- 70 LAMBSQUARTER --      -- -- -- -- -- -- -- -- -- 100 100 100 100 100 90 80 40  100 100 0 50 70      90 30 60 80 100 CHICK WEED                  0 30 80 100 30 70 90 100  50      70 80 

What is claimed is:
 1. A compound of the formula: ##STR524## wherein J is ##STR525## wherein R is H or CH₃ ;E is a single bond or CH₂ ; W is O, S or NR_(x) ; R_(x) is H, C₁ -C₃ alkyl or C₁ -C₃ alkoxy; R₁ is H, F, Cl, Br, C₁ -C₃ alkyl, C₁ -C₃ haloalkyl, C₁ -C₃ alkoxy, C₁ -C₃ haloalkoxy or C₁ -C₃ thioalkyl; R₂ is H, Cl, Br, F, C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, cyclopropyl optionally substituted by 1-4 halogen, cyclobutyl optionally substituted by 1-4 halogen, C₂ -C₄ alkenyl optionally substituted by halogen, C₂ -C₄ alkynyl optionally substituted by halogen, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₃ -C₄ alkenyloxy, C₃ -C₄ alkynyloxy, NO₂, CO₂ R₃, NR₄ R₅, S(O)_(n) R₆, SO₂ NR₇ R₈, C(O)NR₉ R₁₀, ##STR526## n is 0, 1 or 2; R₃ is C₁ -C₃ alkyl, C₂ -C₃ haloalkyl, C₁ -C₃ alkoxy, C₃ -C₄ alkenyl, CH₂ (C₃ -C₅ cycloalkyl) or C₃ -C₄ alkynyl; R₄ is H or C₁ -C₂ alkyl; R₅ is C₁ -C₂ alkyl; R₆ is C₁ -C₄ alkyl, C₃ -C₄ alkenyl, C₂ -C₄ alkoxyalkyl or C₁ -C₃ haloalkyl; R₇ is H or C₁ -C₂ alkyl; R₈ is C₁ -C₂ alkyl or C₁ -C₂ alkoxy; R₉ is H or C₁ -C₃ alkyl;R₁₀ is C₁ -C₃ alkyl; R₁₁ is H or CH₃ ; R₁₂ is H or CH₃ ; R₁₃ is H, C₁ -C₃ alkyl, allyl, C₁ -C₃ haloalkyl or C₁ -C₃ alkyl substituted with C₁ -C₂ alkoxy; R₁₃ ' is H, C₁ -C₃ alkyl, C₁ -C₃ haloalkyl, allyl, C₁ -C₂ alkoxy, C₁ -C₂ haloalkoxy or C₁ -C₂ alkylthio; R₁₃ " is H, C₁ -C₃ alkyl, allyl or C₁ -C₃ haloalkyl; R₁₄ is C₁ -C₃ alkyl, CH₂ OCH₃ or CH₂ CN; ##STR527## X is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkyl, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, halogen, C₂ -C₅ alkoxyalkyl, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino or di(C₁ -C₃ alkyl)amino; Y is H, C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₁ -C₄ haloalkylthio, C₁ -C₄ alkylthio, C₂ -C₅ alkoxyalkyl, C₂ -C₅ alkoxyalkoxy, amino, C₁ -C₃ alkylamino, di(C₁ -C₃ alkyl)amino, C₃ -C₄ alkenyloxy, C₃ -C₄ alkynyloxy, C₂ -C₅ alkylthioalkyl, C₂ -C₅ alkylsulfinylalkyl, C₂ -C₅ alkylsulfonylalkyl, C₁ -C₄ haloalkyl, C₂ -C₄ alkynyl, C₃ -C₅ cycloalkyl, azido, cyano, ##STR528## or N(OCH₃)CH₃ ; m is 2 or 3; Q₁ and Q₂ are independently O or S; R_(a) is H or C₁ -C₃ alkyl; R_(b) and R_(c) are independently C₁ -C₃ alkyl; and Z is CH, CCH₃, CC₂ H₅, CCl or CBr;and their agriculturally suitable salts; provided that (1) when X is halogen, then Z is CH and Y is OCH₃, OC₂ H₅, NH₂, NHCH₃, N(CH₃)₂, OCF₂ H, OCF₂ Br or N(OCH₃)CH₃ ; (2) when W is S, then R is H, E is a single bond, Z is CH and Y is CH₃, OCH₃, OC₂ H₅, CHHd 2OCH₃, C₂ H₅, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ .tbd.CH, OCH₂ CH₂ OCH₃, CH(OCH₃)₂ or ##STR529## nd (3) when the total number of carbon atoms of X and Y is greater than four, then the combined number of carbons of R₁ and R₂ is less than or equal to six and (4) when X or Y is C₁ haloalkoxy, then Z is CH.
 2. A compound of claim 1 whereX is C₁ -C₂ alkyl, C₁ -C₂ alkoxy, Cl, F, Br, I, OCF₂ H, CH₂ F, CF₃, OCH₂ CH₂ F, OCH₂ CHF₂, OCH₂ CF₃, CH₂ Cl or CH₂ Br; and Y is H, C₁ -C₂ alkyl, C₁ -C₂ alkoxy, CH₂ OCH₃, CH₂ OCH₂ CH₃, NHCH₃, N(OCH₃)CH₃, N(CH₃)₂, CF₃, SCH₃, OCH₂ CH═CH₂, OCH₂ C.tbd.CH, OCH₂ CH₂ OCH₃, CH₂ SCH₃, C(O)R_(a), ##STR530## OCF₂ H, SCF₂ H, OCF₂ Br, cyclopropyl, C.tbd.CH or C.tbd.CCH₃ ; Z is CH; and R_(a) is H or CH₃.
 3. A compound of claim 2 whereE is a single bond; W is O; and R₁ is H, F, Cl, Br, CH₃, C₁ haloalkyl or OCH₃.
 4. A compound of claim 2 whereE is CH₂ ; W is O; and R₁ is H, F, Cl, Br, CH₃ or OCH₃.
 5. A compound of claim 3 whereR₂ is H, Cl, Br, F, C₁ -C₂ alkyl, C₁ -C₂ haloalkyl, cyclopropyl, C₁ -C₂ alkoxy, C₁ -C₂ haloalkoxy, CF═CFCl, CF═CFCF₃, NO₂, CO₂ R₃, NR₄ R₅, S(O)_(n) R₆, SO₂ NR₇ R₈, SO₂ N(OCH₃)CH₃, C(O)NR₉ R₁₀, R₂ -A, R₂ -B, R₂ -E, R₂ -J, R₂ -N, R₂ -Q, R₂ -R, R₂ -X, R₂ -Y, R₂ -AB, R₂ -AC or R₂ -AD; R₃ is CH₃, CH₂ CH₃, CH₂ CH₂ OCH₃ or CH₂ CH₂ Cl; R₄ is H or CH₃ ; R₆ is C₁ -C₃ alkyl, C₁ -C₃ haloalkyl or allyl; R₇ is H or CH₃ ; R₈ is C₁ -C₂ alkyl R₉ is H or CH₃ ; R₁₀ is CH₃ or CH₂ CH₃ ; R₁₃ is H, CH₃, CH₂ CH₃ or CH₂ CH₂ OCH₃ ; and R₁₃ " is H, CH₃ or CH₂ CH₃.
 6. A compound of claim 5 whereX is CH₃, OCH₃, OCH₂ CH₃, Cl, OCF₂ H or OCH₂ CF₃ ; Y is CH₃, OCH₃, CH₂ CH₃, CH₂ OCH₃, NHCH₃ or CH(OCH₃)₂.
 7. A compound of claim 6 where J is J-1.
 8. A compound of claim 6 where J is J-2.
 9. A compound of claim 6 where J is J-3.
 10. A compound of claim 6 where J is J-4.
 11. The compound of claim 1 which is N-[(4,6-dimethoxypyrimidin-2-yl)aminocarbonyl]-3-methyl-2-pyridinesulfonamide-1-oxide.
 12. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of the compound of claim 1 and at least one of the following: surfactant, solid or liquid diluent.
 13. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of the compound of claim 2 and at least one of the following: surfactant, solid or liquid diluent.
 14. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of the compound of claim 3 and at least one of the following: surfactant, solid or liquid diluent.
 15. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of the compound of claim 4 and at least one of the following: surfactant, solid or liquid diluent.
 16. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of the compound of claim 5 and at least one of the following: surfactant, solid or liquid diluent.
 17. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of the compound of claim 6 and at least one of the following: surfactant, solid or liquid diluent.
 18. A composition suitable for controlling the growth of undesired vegetation which comprises an effective amount of the compound of claim 11 and at least one of the following: surfactant, solid or liquid diluent.
 19. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of the compound of claim
 1. 20. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of the compound of claim
 2. 21. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of the compound of claim
 3. 22. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of the compound of claim
 4. 23. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of the compound of claim
 5. 24. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of the compound of claim
 6. 25. A method for controlling the growth of undesired vegetation which comprises applying to the locus to be protected an effective amount of the compound of claim
 11. 